Have you ever tried getting your facts from reputable science journals, try smthg different
I'll see your obscure internet BS and raise you one peer-reviewed study :
Consumption of Saturated Fat Impairs the
Anti-Inflammatory Properties of High-Density
Lipoproteins and Endothelial Function
J Am Coll Cardiol, 2006; 48:715-720, © 2006 by the
OBJECTIVES: The purpose of this study was to
investigate the influence of dietary fatty acids on
the anti-inflammatory properties of high-density
lipoproteins (HDL) and vascular function.
BACKGROUND: The effect of dietary fatty acids on
atherogenesis remains uncertain.
METHODS: Fourteen adults consumed an isocaloric meal
containing either a polyunsaturated or a saturated fat
on 2 occasions. The effects of post-prandial HDL on
endothelial cell expression of intercellular adhesion
molecule-1 (ICAM-1) and vascular cell adhesion
molecule-1 (VCAM-1) were determined. Flow-mediated
dilation (FMD) and microvascular reactivity were
assessed before and 3 and 6 h after the meal.
RESULTS: Plasma triglycerides, insulin, and
nonesterified fatty acids rose after the meals. The
HDL collected 6 h after the saturated meal were less
effective than HDL isolated from fasting plasma in
terms of their ability to inhibit expression of ICAM-1
and VCAM-1, whereas HDL collected 6 h after the
polyunsaturated meal had an inhibitory activity that
was greater than that of HDL collected from fasting
plasma (p < 0.004 and p = 0.01 for comparison of
effect of meals on ICAM-1 and VCAM-1, respectively).
Post-hyperemic microvascular flow significantly
increased at 3 h after the polyunsaturated meal by 45
± 14% and by 21 ± 11% after the saturated meal. The
FMD decreased 3 h after the saturated meal by 2.2 ±
0.9% (p < 0.05 compared with baseline) and by 0.9 ± 1%
after the polyunsaturated meal.
CONCLUSIONS: Consumption of a saturated fat reduces
the anti-inflammatory potential of HDL and impairs
arterial endothelial function. In contrast, the
anti-inflammatory activity of HDL improves after
consumption of polyunsaturated fat. These findings
highlight novel mechanisms by which different dietary
fatty acids may influence key atherogenic processes.
