I have no doubt that we can play the "My scientist" is better than "Your scientist" game, but there is no overwhelming consensus that embryonic cells are not worthy of use for research.
Until we have such strong consensus, use both would be my opinion...
Until we have such strong consensus, use both would be my opinion...
Quote from drmarkan:
Here are some articles to consider in looking at the debate between embryonic and adult stem cells.
http://www.lifesite.net/ldn/2003/nov/03112001.html
Canadian Stem Cell Expert Speaks Out on Adult vs. Embryo Stem Cell Research
Says "embryonic stem cells have yet to be used to treat any form of disease"
TORONTO, November 20, 2003 (LifeSiteNews.com) - Dr. Peter Hollands, who holds a PhD in Stem Cell Biology from Cambridge University in the UK has spoken out on the controversy over adult and embryonic stem cells. In comments to LifeSiteNews.com, Dr. Hollands, who has worked with embryonic stem cells, noted the often overlooked fact that while adult and cord blood stem cells have been widely used for treatments, "embryonic stem cells have yet to be used to treat any form of disease."
Dr. Hollands, who worked as a clinical embryologist at Bourn Hall Clinic - the world's first IVF unit, says that "common sense" dictates that resources be directed toward adult over embryonic stem cell research. "Embryonic stem cells have many legal, moral, ethical and religious objections before even the practicalities of obtaining the cells, growing them, storing them and not least transplanting them are addressed," Dr. Hollands told LifeSiteNews.com. "Adult and umbilical cord blood stem cells are readily available, have no objections associated with them and are tried and tested in clinical use. Umbilical cord blood stem cells, for example, have been used over 3000 times for 45 different diseases!"
With numerous publications to his credit on the subject of stem cells and clinical embryology, Dr. Hollands takes issue with certain other researchers in the field who suggest that embryonic stem cells 'may work better'. A recent finding that adult stem cells can be used to repair muscle tissue, saw one of the researchers involved in the study, UBC's Dr. Fabio Rossi, said that "proposing (adult stem cells) as an alternative to embryonic cells, which may work better, is not the right thing to do." Commenting on Dr. Rossi's statement, Dr. Hollands said, "Why may they work better? We do not even know if they (embryonic stem cells) will work at all! The public must know that adult and umbilical cord blood stem cells are available, proven and ready to use for a range of diseases. We must get away from this idea of the promise of embryonic stem cells and look at the realities of adult and umbilical cord blood stem cells."
Dr. Hollands, who is currently the Scientific Director of Cells for Life, a private cord blood bank in Markham Ontario, also disagreed with those who contend there is a great need to continue study of embryonic stem cells. "We should focus our attention on the most readily available and usable type of cells and these are adult and umbilical cord stem cells. Embryonic stem cells at present are largely political rhetoric and scientific hype. Adult and umbilical cord blood stem cells are proven and ready to use. The public
needs to know this," he said.
http://www.i-sis.org.uk/stemcells2.php
These latest results show that the ES cells need to be genetically modified and extensive manipulation in vitro before they can be transplanted safely. Direct transplant of ES cells are known to give rise to teratomas and uncontrollable cell proliferation. There is already evidence that ES cells are genetically unstable in long term culture, and are especially prone to chromosomal abnormalities. The risks involved in using the cytomegalovirus promoter to drive over-expression of the transcription factor are undetermined. To avoid immune rejection, the ES cells have to be tissue-matched from a bank of stem cells created from âspareâ human embryos. Otherwise, a special human embryo has to be created for the purpose, by transferring the patientâs genetic material into an empty egg, a procedure prone to failure and morally objectionable to many, including scientists.
By contrast, adult stem cells could be transplanted directly without genetic modification or pre-treatments. They simply differentiate according to cues from the surrounding tissues and do not give uncontrollable growth or tumours. The adult stem cells also show high degrees of genomic stability during culture. There is no problem with immune rejection because the cells can readily be isolated from the patients requiring transplant. And there is no moral objection involved. Better yet, research can be directed towards encouraging adult stem cells to regenerate and repair damaged tissues in situ, without the need for cell isolation and in vitro expansion. By minimising intervention, risks are reduced, as well as cost, making the treatment available to everyone and not just the rich.
http://www.globalchange.com/stemcells.htm
http://www.globalchange.com/futurebiotechnology.htm
New evidence that stem cells from bone marrow can become brain cells in humans. Researchers at the US Institute of Neurological Diseases and Stroke have found male brain cells in four women after death who received bone marrow transplants from men. Eva Mezey who led the team, believes stem cells circulate all the time, looking for damaged tissues which they then settle near and repair. Other experiments in adult mice show that bone marrow cells can be persuaded to develop into brain or heart cells. This whole area is very exciting and hugely significant, because it means we probably don't need to develop replacement tissues from embryonic stem cells, thus avoiding all the ethical dilemmas of destroying human embryos for research purposes. It also means that arguments in favour of therapeutic cloning collapse, because adult stem cells are a neater and simpler method of generating other tissues - despite all the campaigning rhetoric by the human cloning community about the benefits to medicine. See more on stem cells. Proceedings of the National Academy of Sciences DOI:10.1073