Risk and reward don't tell the whole story. You need to consider expectation. Your odds of profitability are much lower than mine. When I put on my debit spread, the expectation of FXI expiring below 42 ($10 profit) was 85%. The expectation of it expiring above $42.50 ($40 loss) was 9%. The expectation of expiring in between was 6% (call it $15 loss).
OTM-Options is right but for the wrong reason. It's nuts to trade ITM spreads wherein the bid/ask eats up much of the potential gain. There's no bang for the transaction-cost buck.