As with any potentially powerful technique, gene drives can be misused in a variety of ways or induce unintended consequences.
Gene drives affect all future generations and represent the possibility of a larger change in a living species than has been possible before.[15]
https://en.wikipedia.org/wiki/Gene_drive
Human accelerated regions (HARs), first described in August 2006,[1][2] are a set of 49 segments of the human genome that are conserved throughout vertebrate evolution but are strikingly different in humans. They are named according to their degree of difference between humans and chimpanzees (HAR1 showing the largest degree of human-chimpanzee differences). Found by scanning through genomic databases of multiple species, some of these highly mutated areas may contribute to human-specific traits. Others may represent loss of functional mutations, possibly due to the action of biased gene conversion [2][3] rather than adaptive evolution.
https://en.wikipedia.org/wiki/Human_accelerated_regions
Such action at a distance is extremely common in eucaryotic cells, where gene regulatory proteins bound to sequences thousands of nucleotide pairs from the promoter generally control gene expression. Eucaryotic activators and repressors act by a wide variety of mechanisms—generally causing the local modification of chromatin structure, the assembly of the general transcription factors at the promoter, and the recruitment of RNA polymerase.
https://www.ncbi.nlm.nih.gov/books/NBK26872/
https://en.wikipedia.org/wiki/Broad_Institute
Gene drives affect all future generations and represent the possibility of a larger change in a living species than has been possible before.[15]
https://en.wikipedia.org/wiki/Gene_drive
Human accelerated regions (HARs), first described in August 2006,[1][2] are a set of 49 segments of the human genome that are conserved throughout vertebrate evolution but are strikingly different in humans. They are named according to their degree of difference between humans and chimpanzees (HAR1 showing the largest degree of human-chimpanzee differences). Found by scanning through genomic databases of multiple species, some of these highly mutated areas may contribute to human-specific traits. Others may represent loss of functional mutations, possibly due to the action of biased gene conversion [2][3] rather than adaptive evolution.
https://en.wikipedia.org/wiki/Human_accelerated_regions
Such action at a distance is extremely common in eucaryotic cells, where gene regulatory proteins bound to sequences thousands of nucleotide pairs from the promoter generally control gene expression. Eucaryotic activators and repressors act by a wide variety of mechanisms—generally causing the local modification of chromatin structure, the assembly of the general transcription factors at the promoter, and the recruitment of RNA polymerase.
https://www.ncbi.nlm.nih.gov/books/NBK26872/
https://en.wikipedia.org/wiki/Broad_Institute
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