Quote from easymon1:
Interesting...where could we get specifics on something like that?
Sure

What you want to know? As in - this is really very varying. Currently I have a couple of that cases in reserve:
http://www.aerocool.us/pgs/pgs-q/qx2000.htm
It has 2x 5.25" slot.
Get a standard proper power supply - won't adfvice here, just make it a smaller one if you want to use the 5.25" slots. Nothing special, just make sure it is not overlength deep, which is no problem below 1000 watt or so.
Micro ATX boards? Easy to find. My newswest high end cruncher uses this:
http://www.asus.com/Motherboards/Intel_Socket_2011/Rampage_IV_GENE/
It is freaking expensive but damn good. Got a low height CPU fan, works like a charm. There are plenty of more budget boards around - we talk of standard mATX. Note that THIS board can take a whopping 32gb RAM

SOME boards support ECC RAM, my servers use that based on ASUS / MSI + AMD.
For the more storage oriented servers I have
http://www.supermicro.com/products/accessories/mobilerack/CSE-M28E1.cfm - cost (nearly 400 EUR without taxes) but it is a SAS backplane and I plug a higher end RAID into it

Goes NICELY into the 2x5.25" bays, no joke
The mobos on the server have on board graphics so... I use the large PCIe slots for the RAID card.
Nice, quiet.
In 3 months I move to a new location (finally found a decent house), then I put a rack or 2 to the basement and get my SERVERS there from the data center, but as a smaller solution this setup is great. Have 2 machines running now - 2 servers (discs etc.) and 1 cruncher (only a SSD installed internally, bays empty - that is the expensivbe ASUS board, overclocked "defensive" to 4ghz PER CORE UNDER FULL LOAD...
My own workstation is such a little beast, too, with 6 discs (2 internal, 4 in a
http://www.supermicro.com/products/accessories/mobilerack/CSE-M14.cfm) and a blue ray drive and.... a ATI 6970 graphics card, which definitely is "higher end" (2nd top model from the 6xxx series). The board can take two graphics cards
All expansion I will ever need on my desk.