Wider spreads when hedging.
That's the answer.
No... liquidity, that's the answer... the biggest market is S&P500 and it's derivatives so that pulls a lot of options trading.
The liquidity also dictates the spreads... which arguably should be tighter in SPX than in NDX in that case... but I don't look at NDX so might be wrong there, I doubt it though.
Liquidity liquidity liquidity