This video is great. To answer your question, it may seem like we want to live forever, but at one point, we all get tired.
Who wants to live forever?
- Thread starter Pekelo
- Start date
Aug 23rd of this year will mark the 2nd anniversary of my youngest son's tragic death at the age of 39. I have the same peace that King David had when he said concerning his young son's death "He cannot come to me but I will go to him". I am almost 77 and I have the same energy and zest for life that I had at age 25 because I know that I will live forever and I so look forward to experiencing:
However, as it is written: “What no eye has seen, what no ear has heard, and what no human mind has conceived”— the things God has prepared for those who love him—
In my heart I wonder why it is so easy to discount God and believe that old age is tragic and the "nothingness" of death is a welcomed relief. I enjoyed seeing the picture of Baron and his family enjoying a night out. It hit me then that God said "Male and Female He created them" Now how could nothingness have ever thought that one up.
To believe as you guys do it takes a greater faith than I have, but you are not alone. Stephen Hawking perhaps the most intelligent person of his generation said that because of the Law of Gravity "Something had to come from Nothing -- It was inevitable". Even Hawking's peers pointed out that the Law of Gravity governs what already exists and has no creative power.
Now can you even imagine "Absolute Nothingness"? No molecules, no atoms, no stray electrons, no vacant outer space, no air, no gases, but complete lack of anything. But to then believe that this "Nothingness" went "Bang-Bang" and this magnificent universe was created with precision, order, beauty, and a complete set of finely tuned laws to keep it set in motion and give it stability.
You can believe that if you want but look where it leads you -- To the despair of mortality that Ken Calhoun feels of seeing the sand rapidly drip from the hourglass of his very short life.
That is perhaps the greatest sin of all -- To take the wonder of His creation and give the credit to "Nothingness". God has said "My eternal power and divine nature has been clearly seen, being understood by what has been made, so that man will be without excuse."
So My ET friends, You will live forever, but the question is -- will you live it under God's Blessing or not.
However, as it is written: “What no eye has seen, what no ear has heard, and what no human mind has conceived”— the things God has prepared for those who love him—
In my heart I wonder why it is so easy to discount God and believe that old age is tragic and the "nothingness" of death is a welcomed relief. I enjoyed seeing the picture of Baron and his family enjoying a night out. It hit me then that God said "Male and Female He created them" Now how could nothingness have ever thought that one up.
To believe as you guys do it takes a greater faith than I have, but you are not alone. Stephen Hawking perhaps the most intelligent person of his generation said that because of the Law of Gravity "Something had to come from Nothing -- It was inevitable". Even Hawking's peers pointed out that the Law of Gravity governs what already exists and has no creative power.
Now can you even imagine "Absolute Nothingness"? No molecules, no atoms, no stray electrons, no vacant outer space, no air, no gases, but complete lack of anything. But to then believe that this "Nothingness" went "Bang-Bang" and this magnificent universe was created with precision, order, beauty, and a complete set of finely tuned laws to keep it set in motion and give it stability.
You can believe that if you want but look where it leads you -- To the despair of mortality that Ken Calhoun feels of seeing the sand rapidly drip from the hourglass of his very short life.
That is perhaps the greatest sin of all -- To take the wonder of His creation and give the credit to "Nothingness". God has said "My eternal power and divine nature has been clearly seen, being understood by what has been made, so that man will be without excuse."
So My ET friends, You will live forever, but the question is -- will you live it under God's Blessing or not.
US military will test NAD+ for longevity: (quote from Reddit, link at the bottom)
"StoicOptom
The pill is an NAD precursor MIB-626, being developed by Prof David Sinclair at Harvard.
It is currently an unproven supplement (unsurprisingly that's why it's being tested), but the mouse data is promising.
In the paper published in the journal Cell, NMN, a different NAD precursor, not only restored the physical endurance of old mice on a treadmill, but these old mice ran further than the young, untreated mice. Mice are not humans, so I would not advise taking it, but the research is obviously exciting
For those interested in the mice data, this article summarises it well - https://hms.harvard.edu/news/rewinding-clock
Important to understand what delaying aging refers to exactly (no, it doesn't mean you'll live longer and sicker):
COVID-19 is an example of how it would be a 'no-brainer' for us to intervene on biological aging - preventing disease at a population level is critical for society, healthcare, and the economy. Just like how governments need to make vaccines widely affordable to be effective at a population level, in part to save the economy, it is plausible that targeting aging to 'vaccinate' the population against age-related diseases will be a critical healthcare strategy.
Recently, David Sinclair published a paper with two economics profs at Oxford and London Business School:
We show that a compression of morbidity that improves health is more valuable than further increases in life expectancy, and that targeting aging offers potentially larger economic gains than eradicating individual diseases. We show that a slowdown in aging that increases life expectancy by 1 year is worth US$38 trillion, and by 10 years, US$367 trillion. Ultimately, the more progress that is made in improving how we age, the greater the value of further improvements.
With an aging population, age-related diseases already cost us trillions (see: COVID-19) - the humanitarian and economic value of targeting aging is clear. With the obssession of governments with the economy, these medicines will pay for themselves and be made widely accessible."
"StoicOptom
The pill is an NAD precursor MIB-626, being developed by Prof David Sinclair at Harvard.
It is currently an unproven supplement (unsurprisingly that's why it's being tested), but the mouse data is promising.
In the paper published in the journal Cell, NMN, a different NAD precursor, not only restored the physical endurance of old mice on a treadmill, but these old mice ran further than the young, untreated mice. Mice are not humans, so I would not advise taking it, but the research is obviously exciting
For those interested in the mice data, this article summarises it well - https://hms.harvard.edu/news/rewinding-clock
Important to understand what delaying aging refers to exactly (no, it doesn't mean you'll live longer and sicker):
- Based on decades of animal resesarch, targeting aging would allow us to prevent age-related diseases like cancer, Alzheimer's, stroke, or perhaps even reverse these diseases.
- Aging is the #1 risk factor for chronic disease, and is associated with an accumulation of comorbidities
- Slowing aging generally refers to an increased healthspan, the period of life spent in good health, with increased lifespan coming as a side effect
- Increasing healthspan is basically unique to therapies that slow aging, and it is something that our current 'one disease at a time' approach to medicine is failing to achieve for an aging population
- Diseases like Alzheimer's are more common in the 21st Century, partly because we have delayed the diseases that kill you at earlier ages, like heart attacks and strokes, but aging continues and you develop the next disease in line
- A critical reason why targeting aging is more efficient than trying to cure diseases one at a time is the Taeuber Paradox: a hypothetical cure for cancer or heart disease would add only ~2.5 years to life expectancy, while doing little for the dozens of other diseases we develop w/ age. Also, these 2.5 years would primarily be an increase in lifespan but not healthy lifespan, because the other various comorbidities that acumulate w/ aging have not been dealt with.
- COVID-19 has revealed the vulnerability of our society due to a growing elderly population suffering from biological aging; it confers a ~1000x greater cumulative risk of mortality, while putative risk factors like diabetes and chronic lung disease, are a paltry 2x risk
- To visualise what targeting aging might look like, see: the Mayo Clinic mice
COVID-19 is an example of how it would be a 'no-brainer' for us to intervene on biological aging - preventing disease at a population level is critical for society, healthcare, and the economy. Just like how governments need to make vaccines widely affordable to be effective at a population level, in part to save the economy, it is plausible that targeting aging to 'vaccinate' the population against age-related diseases will be a critical healthcare strategy.
Recently, David Sinclair published a paper with two economics profs at Oxford and London Business School:
We show that a compression of morbidity that improves health is more valuable than further increases in life expectancy, and that targeting aging offers potentially larger economic gains than eradicating individual diseases. We show that a slowdown in aging that increases life expectancy by 1 year is worth US$38 trillion, and by 10 years, US$367 trillion. Ultimately, the more progress that is made in improving how we age, the greater the value of further improvements.
With an aging population, age-related diseases already cost us trillions (see: COVID-19) - the humanitarian and economic value of targeting aging is clear. With the obssession of governments with the economy, these medicines will pay for themselves and be made widely accessible."
Last edited:
@Baron will be interested in this comment (from the previous reddit thread):
"thewhitedog:
It's out already, I'm 48, have been taking liposomal NMN for almost a month now and it's doing something, have more stamina in workouts, girlfriend swears my skin looks nicer but not sure if she's reading too much into it haha. The big thing will be to see if the few grey hairs in my beard turn brown again which some people report happening."
"I get mine from Alivebyscience - www.reddit.com/r/AlivebyScience/"
"I'm taking the liposomal NMN capsules, the lipo sublingual fistein, I got the nad+ nasal spray, and the renue serum and moisterizer for my skin. I sort of went all-in on this to see if it works. So far, something seems to be working, def notice it while working out, but will see how it goes long term. Next step is to get my bloods etc done, plus regular photos so I can track if it works.
I turn 50 in 2 years and it's a mindfuck. Have no interest in being physically elderly."
"The energy thing, no, sorry, it's clear that is working. Endurance is definitely more than before. The effect is consistent across all workouts (and, frankly, in bed as well) and the physical feeling associated with exertion is noticeably different, been trying to think of a dispassionate way to describe it but failing - it's like a fizzing, satisfying sensation.
In the mouse studies Sinclair ran they said the older mice given the NMN broke the treadmill from running too long, I don't have anywhere near that dramatic an effect but at peak exertion there's "more in the tank" than before and it actually feels good rather than before when I would be gassing out and not enjoying it."
------------------------------------------
Another poster:
"wowthatssorude
Also my experience. NR (nicotinamide riboside) I saw mental energy up, sharper more focus. And my calves do not cramp. At all. On feet 12hrs a day at factory. When I stop taking NR my cramps come back within a week. Workouts go better. In general I train harder with more focus and feel less wasted after a work out. NR I did 600mg a day (too expensive though why I don’t now)
NMN sublingually about the same effect just less so. I only did 300-400mg daily (I never exactly measured my powder everytime). subjectively I think I liked NR more. Although I did take more mg consistently.
I had better days with NMN vs nothing. But the NR I noticed I just had more bounce. And definitely less pains, that I’m sure. Hips, lower back and neck didn’t hurt as much. And my calves basically every day, were cramp free.
I’ll try doing 500-800 NMN next time to see if more is better.
Just want these things cheaper.
I feel good to with 1g of Niacin (regular nicotinic acid. The flushy kind). Not quiet what NR gave me.
And Nicotinamide honestly I feel great on and it’s cheap. I know it can suppress sirt1 but I’m sure we need more data about how much and if it fluctuates. Even if NMN does increase sirt1, it’s also suppressing it if most breaks down to nicotinamide too……sooooo. More data needed.
Just my experience of a year trying each for months at a time. I’m not a research study. Just a guy with an anecdote."
"thewhitedog:
It's out already, I'm 48, have been taking liposomal NMN for almost a month now and it's doing something, have more stamina in workouts, girlfriend swears my skin looks nicer but not sure if she's reading too much into it haha. The big thing will be to see if the few grey hairs in my beard turn brown again which some people report happening."
"I get mine from Alivebyscience - www.reddit.com/r/AlivebyScience/"
"I'm taking the liposomal NMN capsules, the lipo sublingual fistein, I got the nad+ nasal spray, and the renue serum and moisterizer for my skin. I sort of went all-in on this to see if it works. So far, something seems to be working, def notice it while working out, but will see how it goes long term. Next step is to get my bloods etc done, plus regular photos so I can track if it works.
I turn 50 in 2 years and it's a mindfuck. Have no interest in being physically elderly."
"The energy thing, no, sorry, it's clear that is working. Endurance is definitely more than before. The effect is consistent across all workouts (and, frankly, in bed as well) and the physical feeling associated with exertion is noticeably different, been trying to think of a dispassionate way to describe it but failing - it's like a fizzing, satisfying sensation.
In the mouse studies Sinclair ran they said the older mice given the NMN broke the treadmill from running too long, I don't have anywhere near that dramatic an effect but at peak exertion there's "more in the tank" than before and it actually feels good rather than before when I would be gassing out and not enjoying it."
------------------------------------------
Another poster:
"wowthatssorude
Also my experience. NR (nicotinamide riboside) I saw mental energy up, sharper more focus. And my calves do not cramp. At all. On feet 12hrs a day at factory. When I stop taking NR my cramps come back within a week. Workouts go better. In general I train harder with more focus and feel less wasted after a work out. NR I did 600mg a day (too expensive though why I don’t now)
NMN sublingually about the same effect just less so. I only did 300-400mg daily (I never exactly measured my powder everytime). subjectively I think I liked NR more. Although I did take more mg consistently.
I had better days with NMN vs nothing. But the NR I noticed I just had more bounce. And definitely less pains, that I’m sure. Hips, lower back and neck didn’t hurt as much. And my calves basically every day, were cramp free.
I’ll try doing 500-800 NMN next time to see if more is better.
Just want these things cheaper.
I feel good to with 1g of Niacin (regular nicotinic acid. The flushy kind). Not quiet what NR gave me.
And Nicotinamide honestly I feel great on and it’s cheap. I know it can suppress sirt1 but I’m sure we need more data about how much and if it fluctuates. Even if NMN does increase sirt1, it’s also suppressing it if most breaks down to nicotinamide too……sooooo. More data needed.
Just my experience of a year trying each for months at a time. I’m not a research study. Just a guy with an anecdote."
Last edited:
"In my experience, NAD+ enhancers are a money grab. Metformin and Rapamycin are where the action is (or, will be). Check out Peter Attia's podcasts.:"
https://peterattiamd.com/joanmannick-nirbarzilai/
"In this episode, Joan and Nir discuss their extensive research into rapamycin (including the category of analogs to rapamycin known as rapalogs) and metformin, respectively. Based on his work with metformin, Nir shares how he believes it could be a pro-longevity drug and the clinical trial he’s leading to test this belief. Joan discusses her work with rapalogs, their ability to suppress the immune system as well as provide immune-enhancement, and the clinical trials she has led that inform her insights. We also talk about the potential beneficial roles of both metformin and rapamycin in reducing mortality from COVID-19, reducing the risk of neurodegenerative diseases, and delaying aging as well as its related diseases."
https://peterattiamd.com/joanmannick-nirbarzilai/
"In this episode, Joan and Nir discuss their extensive research into rapamycin (including the category of analogs to rapamycin known as rapalogs) and metformin, respectively. Based on his work with metformin, Nir shares how he believes it could be a pro-longevity drug and the clinical trial he’s leading to test this belief. Joan discusses her work with rapalogs, their ability to suppress the immune system as well as provide immune-enhancement, and the clinical trials she has led that inform her insights. We also talk about the potential beneficial roles of both metformin and rapamycin in reducing mortality from COVID-19, reducing the risk of neurodegenerative diseases, and delaying aging as well as its related diseases."
