I highly recommend you read up on the new batch of Covid vaccines in early phase trials that are for targeting the N protein...the most abundant viral protein and is highly immunogenic during CoV (covid) infections.
In immunology, it's the primary target for antibody responses that has an additional plus because it contains T cell epitopes.
Yet, Covid vaccines that target the N protein have been causing a mess in the body of tested animals by producing enhanced infection-induced pneumonia via increased pulmonary eosinophil infiltration and TH2 cell-biased responses, causing ERD.
It's the reason why in the beginning they decided to not focus on CoV vaccines that targeted N proteins and produced N-antibodies. In contrast, the body naturally produces it much better but the problem there...you would kill off and injure a larger percentage of the global population trying to achieve natural immunity.
- Study the history of Influenza and Smallpox when there were no vaccines...just hope for natural immunity.
Now that we're nearing the conclusion of the Pandemic...there's been a shift towards other types of CoV vaccines to target the N, E, and M proteins for humoral immune responses...the latter two (E and M) so far have produced inadequate immune responses which is why newer covid vaccine research in early phase trials are focusing on the N proteins.
I remember back last summer (2021) there was a news announcement by the vaccine makers that they were working on newer vaccines that target other proteins instead of the S protein. I assumed they were talking about the N.E.M. proteins.
- The advantages are economically much better (cheaper) and they would not require low-temperature storage.
There are others researching a combo vaccine that targets S.N.E.M. proteins to protect against Covid infections of the lungs and brain. I think we're a few years away from that especially if most of the world lose interest (getting back to a normal way of living) as we traverse from a Pandemic into an Endemic.
- Regardless, a new Covid vaccine for the N protein that does not cause enhanced pneumonia would be huge news considering it should result in a better economic cost.
Ironically, many of them that spread misinformation/disinformation were vaccinated when vaccines became available instead of waiting many years in hope of developing natural immunity which is why I believe the same is true today in the Covid Pandemic.
Rich people can shelter much better than the poor. That was true during smallpox and prior Pandemics as they wait it out until the disease rips deadly through the global population.
P.S. A wealthy friend of mine from Indiana, she and her family have been living in Hawaii during this entire Pandemic...one of the states with the least Covid spread and Covid deaths.
She said they'll return back to Indiana when people are more socially responsible with Covid. Yet, their kids are loving it in Hawaii and don't want to go back to Indiana.
wrbtrader
Last edited:
