I'm going to use the term "private equity/private prospectus" to encompass terminology for all substantial backers who will let you speculate for serious $$ on their dime: hedge funds, certain prop firms and black label private equity funds.
A big eye-opener for my clients is getting a perspective on what strategies attract funding. In other words, you must tempt the principal's greed and simultaneously soothe the risk manager.
Buying IBM three year paper and selling CBOT two-year note futures as a spread position will raise eyebrows and attract attention amongst the greediest of money-changers. It is easily funded because of the quality of the instruments and can be ridiculously leveraged. Sadly, shorting two-year notes flat price directional is not sexy. And it's expensive given the leverage - since you're not long the underlying, the credit facility will treat you like a fat chick with AIDS (it's a collateral thing).
Will the short 2-Yr Note position ultimately be more profitable? Quite possibly, if you can get it funded accordingly. (If you feel that strongly about it, why not just sell some duration like a man's man?).
It's not really fair, because the short naked 2-Yr position may carry less risk and ultimately be more profitable than a highly leveraged spread position - after all, look what happened to LTCM.
So, my point is this: be good at something that attracts both risk managers and the money-changers (because after you leave the pitch presentation, they both vote).