Only one has the potential to really wipe out your account.
However given that some losses are inevitable, then if you miss enough profits then those missed profits will also result in an eventual wipeout.
Also consider:
A) Taking losses that are a part of your rules
B) Taking losses that are outside your rules.
Type A losses are not supposed to be bad at all (assuming you have edge)
Type B losses are really bad especially if you are doing so on a regular basis, they have the potential to negate your edge.
Likewise enough missed profits also have the potential to negate your edge.
And a negative edge will eventually lead to a wipeout.