If you use IB, look at IB's Risk Navigator software. It takes a bit of effort to get used to, but overall its pretty comprehensive on managing your portfolio risk by underlying, regions, industries and long/short and diving in by greeks, all in real-time. Addtionally, gives multiple measures for VaR that you can tune for various time-periods. For a few things that I find missing (real-time margin req by underlying, liquidity risk, net option long/short etc.) I've written some scripts to generate these for me.
Some commercial software that does similar things that I've looked at were Silexx Financial Systems and StatPro's Portfolio Analysis. Bloomberg has something called PORT that does portfolio risk analytics on their platform. These are all cost prohibitive and personally, most folks can make most everything work with IB Risk Navigator and IB's api's.
Nonetheless, I'm interested on what you find out. I frequently evaluate Risk management software to see if it makes sense in my system.