We set a stop-loss level at the time of trade entry. If our proprietary studies reverse, then the technical conditions for entering the trade are no longer valid and that gets us out. I have found through the years that about half of my losses are taken through technical failure before the stop-loss level is reached.
In other words, for losses it's an either/or scenario - we either get stopped out at the original "uncle" point we set at the time of the trade entry, or the study reverses.