If you mean Microsoft Excel on Linux, that's pretty much impossible as far as I know but if you're talking about the Excel file format, depending on what you're looking for, there are a bunch of readers out there. Worst case: import to Google sheets then use the API to extract the data you're looking for.
Setup Excel/Word/Powerpoint on Ubuntu Linux in early 00's. Worked fine for what I set it up for, but you don't get thing slike DDE and proper OS/GUI integrations (drag & drop, clipboard objects, shortcuts etc.). The secret wine was Wine, older versions of Office should be possible to run. But I don't recommend it, as it's more trial by fire, than anything else, not supported. Crossover or similar might offer some paid support though, never tried it.
With today's hardware, you're really better off running VM, on a real desktop comp with lots of mem, not the hot laptop shit. ReactOS is interesting, if it ever got good compatibility, which is probably near impossible. It'll probably be too late when it's ready.
Your best bet is to bet on Free/GPL'ed Software, but remain flexible using VMs. For non-techies, Winblows or Mac probably OK for them still. Unfortunately, you won't be able to abuse LibreOffice as you can with Excel. There what you can do with formulas and <200 MB files is pretty darn impressive. Though, Excel is probably wrong choice for anything more complex than a simple multi-column list.
In the end, use what works. Tech comes last unless it becomes bottleneck.