Most things work, just are they being applied well enough.
I use VWAP as a universal reference point a lot and I have a trade or two based on pretty reliable behaviours around it. The volume profile.. meh, useful for some I'm sure but after a couple of years you can just look left on the chart and see all you need.
Gap closes in the ES etc. can make nice money with orders waiting etc. though large midweek gaps like yesterday are rare/world event things.