The issues are what divide, not to mention brain structure/physiology/upbringing,place
Here are the main ones, let me know if I forgot any:
Gun control or lack thereof.
Freedom from religious delusions in govt affairs, I mean freedom of religion and being able to believe any old crazy shit.
Man made global warming/science/environment/quality of life and health.
The poor and disadvantaged. Like that guy Jesus talked about.
Abortion rights vs rights of the unborn. This is a tough one.
Govt good vs govt bad.
Dept of Offense, I mean war, military industrial complex/military readiness - to invade other smaller countries at will.
Nationalism vs Globalism
Social welfare/safety net vs "tough luck , you are on your own, hop along on that one good leg" - see Jesus, above.
Capitalism vs Socialism.
Wealth distribution vs those with the most wins. See Jesus, above.
Plutocracy vs Democracy, see "money in politics"
Tribalism vs pan-racism. See Jesus, above.
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So in all these case above, the dems/progressives win. In each case above conservatives are on the wrong side. Mostly they are the wrong side of what Jesus said. Which is ironic.