Quote from Tech Analysis:
I'm not so sure you can run multiple instances of esignal at once. I was running esignal and accidently hit it again on the Start Menu and the damn thing totally crashed and wrecked part of my layout.
As for 2+ simultaneous computers - definitely not. They do offer volume license discounts; I've spoken w/CS rep about it.
As far as I can tell, the only way to get esignal to run on multiple screens is to bring up multiple instances since esignal does not use a multiple document interface. You'd have one layout and set of charts for the left screen and a second for the right. Since files aren't shared, hopefully this would not cause a crash.