I specialize in relatively low volume stocks, preferring ones with volume over 250K. However, there are some that I trade that are below that cutoff point. I've trading these low volume "wonders" to be somewhat of an art.
One example of an exception is AZZ that has very low volume but I've made money on it consistently. Extreme patience is needed, sometimes I had to wait an hour or more for fills. Most of my trades in it have been longs as getting short fills is very difficult.
In general, I've found that some of these low volume stocks tend to test well (I use Tradestation) but trade poorly with big spreads and poor fills erasing the "theoretical profits". And, it is difficult to factor in a standard "slippage/commission" for them as it varies day by day, time of day and who knows what other factors.
Doug S