Thinly traded Nasdaq stocks are indeed suicide.
I will never forget being stuck in a fairly large position of NVLS about 4 or 5 years ago. NVLS is not even really a thin stock compared to so many. But because it was at lunch time, there were virtually no trades going off. The spread was large enough that if I could have sold at the offer, I would have made that one trade a very profitable day. If I sold at the bid, I was a big loser on the day.
For one of the longest hours of my day trading career, I sat and tried to get a fill somewhere in the middle. I had an Instinet terminal on my desk as well as a level 2. I would put out an order in Inca. It would time out. Try Select Net, cancel. Try Inca again. Etc.
I learned two things that day. Don't trade thin issues. And don't trade at noon.
And of course, to make it all worse, I was absolutely starving at the time, but couldn't walk away to get food.
I am sure there are traders here that remember PRST, when it could have a $20 or $30 spread. Novellus was never quite that crazy, but no one I ever knew of traded PRST in size. (what ever became of PRST? Is it now a penny stock?)
Bottom line....like everyone here says.....trade thick stocks. There is no way to win when you are subjected to huge spreads and greedy market makers. And maybe it isn't even that they are so greedy. It's hard even for them to trade those stocks. That's why the large spreads. Low volume should be self explanatory.
Look at the pink sheets (if they still exist). Take a look at the spreads there. No buyers, no sellers. HUGE spreads. Maybe a 3 cent spread doesn't sound so big, but if the market is $.01 x $.04, well tripling the bid to break even seems a bit rough.
Stick with the easy stuff. Trade listed...Trade BRK with a $600 spread, and get it out of your system.

rs7