The Coronavirus Is Here Forever

[gwb-trading]

Guess what I just found out about the Horse Tranquilizer you were calling me retarded for saying it is a drug.
It won the Nobel Prize for a human drug.
Pretty good for a retard, eh? eh?
https://www.sciencedirect.com/science/article/pii/S2052297521000883

And yet the scientists who did the research say the drug should not be used for treating Covid-19.

And the manufacturer of the drug, Merck, states Ivermectin should not be used for treating Covid-19.

 

[Bugenhagen]

Guess what I just found out about the Horse Tranquilizer you were calling me retarded for saying it is a drug.
It won the Nobel Prize for a human drug.
Pretty good for a retard, eh? eh?
https://www.sciencedirect.com/science/article/pii/S2052297521000883

You mean the Irish Nobel lauriate Campbell (shared with the Japanese researcher) who makes no claims that its an effective drug against Covid-19? I'm Irish too, last I heard on the Irish Web radio was his concerns about misguided use/abuse and proper research.

If something can be found to overcome the issue of the lungs being an excellent filter and stopping Ivermectin achieving sufficient concentration to be useful in vivo (last I heard this was the primary issue) then great. Well assuming it does not have side effects through this. But there are many other drugs that do work.

Who's a retard? You are a retard. Don't drag William Campbell into yours. I am little bit retard though for replying to you my little fart sniffer.

 

[wrbtrader]

And yet the scientists who did the research say the drug should not be used for treating Covid-19.

And the manufacturer of the drug, Merck, states Ivermectin should not be used for treating Covid-19.

Are these people low IQ or something when they see a drug developed and used for the treatment of intestinal parasites in humans...

They then think it's suitable as an antiviral treatment of Covid even after the person and company that make the drug state it's NOT suitable for the treatment of Covid.

Yeah, it's possible that may change one day in the future but that one day is not today.

wrbtrader

 

[Bugenhagen]

Are these people low IQ or something when they see a drug developed and used for the treatment of intestinal parasites in humans...

They then think it's suitable as an antiviral treatment of Covid even after the person and company that make the drug state it's NOT suitable for the treatment of Covid.

Yeah, it's possible that may change one day in the future but that one day is not today.

wrbtrader

In addition the hypothesis that de-worming people who live in parasite endemic areas would help their immune response to covid-19 has taken a knock with this study showing people with intestinal parasites have a better chance not worse. It's not conclusive yet of course.

I hazard this is like the way respitory viral infections block each other. With the immune system already at action stations, a new infection has little chance.

In addition to:

"Parasite-driven immunomodulatory responses may mute hyper-inflammation associated with severe COVID-19."

https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(21)00334-5/fulltext#

 

[Cuddles]

Are these people low IQ or something when they see a drug developed and used for the treatment of intestinal parasites in humans...

They then think it's suitable as an antiviral treatment of Covid even after the person and company that make the drug state it's NOT suitable for the treatment of Covid.

Yeah, it's possible that may change one day in the future but that one day is not today.

wrbtrader

The thesis is Ivermectin has anti-viral properties (which was shown successfully in trials for other viruses by disrupting some mechanism); similar thesis as HCL. It's not as cut and dry as "an anti-parasitic can't be an antiviral". There's good info on the wiki for it.

sigh....

https://en.wikipedia.org/wiki/Ivermectin#Research
https://en.wikipedia.org/wiki/Ivermectin#Tropical_diseases

Although several clinical trials are now underway to test possible therapies, the worldwide response to the COVID-19 outbreak has been largely limited to monitoring/containment. We report here that Ivermectin, an FDA-approved anti-parasitic previously shown to have broad-spectrum anti-viral activity in vitro, is an inhibitor of the causative virus (SARS-CoV-2), with a single addition to Vero-hSLAM cells 2 h post infection with SARS-CoV-2 able to effect ~5000-fold reduction in viral RNA at 48 h. Ivermectin therefore warrants further investigation for possible benefits in humans.

Targeting host responses to invading viruses has been the focus of recent antiviral research. Venezuelan Equine Encephalitis Virus (VEEV) is able to modulate host transcription and block nuclear trafficking at least partially due to its capsid protein forming a complex with the host proteins importin α/β1 and CRM1. We hypothesized that disrupting the interaction of capsid with importin α/β1 or the interaction of capsid with CRM1 would alter capsid localization, thereby lowering viral titers in vitro. siRNA mediated knockdown of importin α, importin β1, and CRM1 altered capsid localization, confirming their role in modulating capsid trafficking. Mifepristone and ivermectin, inhibitors of importin α/β-mediated import, were able to reduce nuclear-associated capsid, while leptomycin B, a potent CRM1 inhibitor, confined capsid to the nucleus. In addition to altering the level and distribution of capsid, the three inhibitors were able to reduce viral titers in a relevant mammalian cell line with varying degrees of efficacy. The inhibitors were also able to reduce the cytopathic effects associated with VEEV infection, hinting that nuclear import inhibitors may be protecting cells from apoptosis in addition to disrupting the function of an essential viral protein. Our results confirm that VEEV uses host importins and exportins during part of its life cycle. Further, it suggests that temporarily targeting host proteins that are hijacked for use by viruses is a viable antiviral therapy. © 2013 Elsevier B.V. All rights reserved.

Infection by one of the 4 distinct serotypes of dengue virus (DENV) threatens >40% of the world's population, with no efficacious vaccine or antiviral agent currently available. DENV replication through the virus-encoded nonstructural protein (NS) 5 protein occurs in the infected cell cytoplasm, but NS5 from DENV2 has thus far been shown to localize strongly in the nucleus throughout infection. Here we use specific antibodies cross-reactive with NS5 from DENV1-4 to demonstrate nuclear localization of NS5 from all DENV serotypes for the first time in both infected as well as transfected cells, although to differing extents. The small-molecule inhibitor Ivermectin was inhibitory towards both DENV 1 and 2 NS5 interaction with its nuclear transporter importin α/β in vitro, and protected against infection from DENV1-4. Ivermectin thus has potential in the clinical setting as a dengue antiviral. © 2013 Elsevier B.V.

The movement of proteins between the cytoplasm and nucleus mediated by the importin superfamily of proteins is essential to many cellular processes, including differentiation and development, and is critical to disease states such as viral disease and oncogenesis.We recently developed a high-throughput screen to identify specific and general inhibitors of protein nuclear import, from which ivermectin was identified as a potential inhibitor of importin α/β-mediated transport. In the present study, we characterized in detail the nuclear transport inhibitory properties of ivermectin, demonstrating that it is a broad-spectrum inhibitor of importin α/β nuclear import, with no effect on a range of other nuclear import pathways, including that mediated by importin β1 alone. Importantly, we establish for the first time that ivermectin has potent antiviral activity towards both HIV-1 and dengue virus, both of which are strongly reliant on importin α/βnuclear import, with respect to the HIV-1 integrase and NS5 (non-structural protein 5) polymerase proteins respectively. Ivermectin would appear to be an invaluable tool for the study of protein nuclear import, as well as the basis for future development of antiviral agents. © The Authors Journal compilation © 2012 Biochemical Society.

sure, sure, russian trolls went years back in time and published those studies & quack doctors were doing research to push misinformation a month into the pandemic.

https://www.abc.net.au/radionational/programs/healthreport/coronavirus-ivermectin-drug/12125192

https://research.monash.edu/en/projects/ivermectin-as-an-anti-viral-against-sars-cov-2

https://research.monash.edu/en/persons/kylie-wagstaff

 

[Bugenhagen]

The thesis is Ivermectin has anti-viral properties (which has shown successfully in trials for other viruses by disrupting some mechanism); similar thesis as HCL. It's not as cut and dry as "an anti-parasitic can't be an antiviral". There's good info on the wiki for it.

The issue has been getting enough of the drug where it needs to be in clinically significant levels, safely.

A dumbo rat (twice removed) republican gets his Ivermectin.

This appears to work, high concentration in the lungs, nobody is surprised.

Now.. Most people with an education have a gist one needs to be careful with nebulised drugs as its about the same as injecting into the vein. The Ivermectinite Church seems to understand that promoting this approach which WILL kill more than they want to take the heat for is a bridge too far. Well unless they are, fuck it.

The Ivermectinite Church not about helping people with covid, it's about those people thinking they owe you their life and shit.

https://www.nature.com/articles/s41598-020-74084-y

Anyhow, it's stupid o'clock and I'm heading south in an Uber, hopefully tonight's Dupinder is a smooth driver as I need to nap.

 

[Cuddles]

The issue has been getting enough of the drug where it needs to be in clinically significant levels, safely.

A dumbo rat (twice removed) republican gets his Ivermectin.
View attachment 267594

This appears to work, high concentration in the lungs, nobody is surprised.

Now.. Most people with an education have a gist one needs to be careful with nebulised drugs as its about the same as injecting into the vein. The Ivermectinite Church seems to understand that promoting this approach which WILL kill more than they want to take the heat for is a bridge too far. Well unless they are, fuck it.

The Ivermectinite Church not about helping people with covid, it's about those people thinking they owe you their life and shit.

https://www.nature.com/articles/s41598-020-74084-y

Anyhow, it's stupid o'clock and I'm heading south in an Uber, hopefully tonight's Dupinder is a smooth driver as I need to nap.

Well, that appears to be the case anyway. The problem is we still have plenty of people outside the states w/o vax and you don't do science by attacking any potentially promising study as "lolz horse dewormer". I still haven't seen the AIIMS prophylactic study disputed. GWB posted a similar one by McGill prof that's the closest I've seen addressing the claim.

The only reason I didn't advocate much for continued HCL use beyond mounting evidence of it not doing anything was the relative complications from overdosing. It's much harder to get to that point w/IVM....until you get idiots sucking cattle dosages who have the resources to get a wildly effective vaccine and easily accessible PPE instead.

 

[Bugenhagen]

until you get idiots sucking cattle dosages who have the resources to get a wildly effective vaccine and easily accessible PPE instead.

Or until they nebulise paste in contaminated tap water.

I decided to delete the post linking to the nebuliser study as there are too many halfwits around but lost signal. Screw it.

I expect some of the mocking it is done knowing that actually a lot of halfwits will be discouraged by this oversimplification. Of course many don't see it as all just compounds.

Of course again, getting the desired concentration does not mean its an effective treatment doing less harm than good.

 

[userque]

Or until they nebulise paste in contaminated tap water.

I decided to delete the post linking to the nebuliser study as there are too many halfwits around but lost signal. Screw it.

I expect some of the mocking it is done knowing that actually a lot of halfwits will be discouraged my this oversimplification. Of course many don't see it as all just compounds.

Of course getting the desired concentration does not mean its an effective treatment doing less harm than good.

I suspect some have already tried this.

Next up is vaping and mainlining.

 

[Bugenhagen]

I suspect some have already tried this.

Next up is vaping and mainlining.