The Biden COVID vaccine

America is about to hit a 'vaccine wall' as demand drops — with or without Johnson & Johnson
https://news.yahoo.com/america-is-a...ith-or-without-johnson-johnson-162241805.html

When U.S. officials temporarily paused the use of Johnson & Johnson’s COVID-19 vaccine Tuesday to warn patients and providers of an “extremely rare” blood clotting issue that has so far affected just six of the millions of Americans who have received the vaccine — all six of them women ages 18 to 48 — many observers worried the abrupt move would stop a substantial number of Americans from getting vaccinated.

But if you take a closer look at the data, it’s clear that unless regulators end up pulling J&J from the market — an outcome experts have all but ruled out, given the vaccine’s robust track record of safety and effectiveness and the relatively minuscule risk of clotting — this week’s (likely brief) time-out may ultimately have little impact on the larger dynamics of America’s vaccination campaign.

Why? Because even before the J&J news, the U.S. was already approaching a “vaccine wall” — the point at which supply outstrips demand, the country’s rapid pace of vaccination starts to slow down and every American who wants a shot can easily get whatever shot they want, whether it’s Pfizer, Moderna or the one-and-done J&J.

The question, then, is whether there will be enough Americans willing to get vaccinated — not whether there will be enough vaccines for Americans who are willing.

By all measures, the U.S. has made remarkable progress on vaccination. When President Biden took office on Jan. 20, the country was administering an average of 900,000 doses a day. Now, less than three months later, the pace has nearly quadrupled to 3.4 million daily doses. On Saturday, 4.6 million shots were reported — a new record. More than 63 percent of U.S. seniors have been fully vaccinated, up from 2 percent at the start of Biden’s term; nearly half of U.S. adults have already gotten at least one jab. And that’s before eligibility has opened up to all Americans 16 or older, a threshold the country is officially set to cross on April 19.

Again, remarkable progress. But things are about to change.

For the next few days or weeks, Americans won’t have access to J&J, and as a result demand for Pfizer and Moderna will rise. As the New York Times reported Tuesday, “mobile vaccine clinics in rural areas” of California and Colorado that depended on J&J doses “were canceled. In Chicago, vaccination events for restaurant employees and aviation workers were postponed indefinitely. At colleges in Ohio, New York and other states, where the one-dose vaccine offered a chance to quickly inoculate students before they left campus for summer, appointments were called off en masse.”

And so “in the very short term, we do expect some impact on daily averages as sites and appointments transition from Johnson & Johnson to Moderna and Pfizer vaccines,” White House pandemic coordinator Jeff Zients explained Tuesday.

But the “very short term” won’t last long. First, as Zients put it Tuesday, the U.S. has “more than enough Pfizer and Moderna vaccine supply to continue or even accelerate the current pace of vaccinations”: 440 million doses to be delivered by the end of May, with an extra 3 million of those doses to be made available while J&J is sidelined this week (during a period when J&J supply was already expected to fall 80 percent because 15 million doses were ruined in a factory mixup). Second, longer-term U.S. supply — which could include up to 200 million Johnson & Johnson doses once this week’s issues are ironed out — will soon start to exceed demand.

In many places it already has. Last week, the New York Times reported that a “pileup of unclaimed appointments in Mississippi” — 73,000 open slots at the time of publication — “reflects … mounting supplies” but also “exposes something more worrisome: the large number of people who are reluctant to get vaccinated.”

Local headlines, meanwhile, are starting to register a similar shift. A few recent examples:

Vaccine demand falls at University of Arizona state POD

“University says thousands of appointments are going unclaimed”

Vaccine demand reaching 'saturation' in Galveston County (Tex.)

“Now we’re moving on to the reluctant, uninformed and hesitant, as well as the people who are just like, ‘Hell no, I don’t want it.’”

Pa. 'incredibly concerned' about falling demand for COVID-19 vaccine as eligibility expands Tuesday

“We’re reaching a tipping point. While we still need more [vaccine] at this stage, it’s going to require us to be more convincing of folks.”

[Wisconsin] health officials 'concerned' about COVID-19 vaccine supply outpacing demand

“After the first rush, the first flood of people who wanted to get the vaccine, it has quieted down significantly."

Vaccine supply increases while demand falters across Ohio

“Vaccine appointments that were once nearly impossible to find now sit unfilled. One reason is more doses are available, but health officials are also seeing a drop in the number of people signing up.”

Mid-Missouri vaccine supply outpacing the demand

“Groups that administer the vaccine are seeing appointment slots go unfilled, even after the state deemed anyone old enough to get the shot eligible last week.”

Signups slow for vaccine appointments [in N.C.]

“Demand for COVID-19 vaccine has declined drastically over the past few weeks.”

Chambers County (Tex.) scaling back COVID-19 vaccination appointments due to decrease in demand

“Despite best efforts to share information regarding appointment availability, the number of people visiting the county-run vaccine clinic has begun to decline.”

The trend is even beginning to surface in New York City, where competition for available doses has been fierce. “For the first time in 4 months, vax appts in NYC are not being immediately filled,” City Council member Mark D. Levine tweeted Wednesday.

The latest CDC numbers reinforce these reports. So far, 14 states have administered less than 75 percent of the doses distributed to them (in ascending order): Alabama, Mississippi, Arkansas, Georgia, Alaska, Wyoming, Louisiana, Tennessee, West Virginia, Florida, Hawaii, Oklahoma, Indiana and South Carolina. Among them, only Hawaii has at least partially vaccinated a larger share of its residents than the national average (about 37 percent).

At the other end of the spectrum, 20 states have administered more than 80 percent of the doses distributed to them (again, in ascending order): Pennsylvania, Washington, Nebraska, Virginia, Connecticut, Colorado, Nevada, New York, Vermont, Iowa, New Mexico, Massachusetts, Utah, Wisconsin, New Jersey, Rhode Island, North Dakota, Minnesota, Maine and New Hampshire. Among them, only North Dakota, Utah and Nevada have at least partially vaccinated a smaller share of their residents than the national average.

The gap between doses distributed and administered can’t perfectly capture differences in demand from state to state; disparities in delivery systems, individual access and data reporting may also play a part.

But roughly speaking, a pattern is emerging: redder, more Republican states across the South and Great Plains are tending to see supply outstrip demand before bluer, more Democratic states in the Northeast and elsewhere.

Compare these two maps created from CDC and Health and Human Services data by Benjy Renton, a researcher tracking the vaccine rollout for Ariadne Labs.

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Note how closely they resemble each other, suggesting a correlation between local vaccine hesitancy and statewide gaps in supply used. Note too how closely they resemble the 2020 U.S. presidential election map.

This tracks with recent polling. According to the latest Yahoo News/YouGov survey, conducted earlier this month, 60 percent of Democrats say they’ve already been vaccinated, versus just 41 percent of Republicans — and the share of unvaccinated Republicans who insist they will “never” get a shot (49 percent) is more than twice as high as the share of unvaccinated Democrats who say the same (23 percent). A separate poll by the Kaiser Family Foundation found that a combined 30 percent of rural Americans say they’ll get vaccinated only if required (9 percent) or they “definitely” won’t get vaccinated at all (21 percent). In suburban areas, that combined number falls to 21 percent; in urban areas, it falls further, to 16 percent.

Yet while Republican areas seem to be hitting the vaccine wall first, the rest of the U.S. will almost certainly follow. According to a report Saturday in the Washington Post, “states have delayed” even “ordering hundreds of thousands of vaccine doses available to them”; at one point last week, 13 states had more than 100,000 doses apiece available and not ordered. And as Renton notes, the gap between doses distributed and administered may be increasing faster in a state like Mississippi than a state like Massachusetts right now — but it’s “increasing in all states” just the same.

A new report from Surgo Ventures, a leading global health data foundation, shows why: Vaccine acceptance, which has steadily risen in recent months, is unlikely to keep rising forever without a shift in strategy.

According to Surgo’s latest survey, a combined 59 percent of U.S. adults now say they’re either already vaccinated or plan to be as soon as the shot is made available to them. At the current rapid pace of vaccination, Surgo concluded, the U.S. is likely to burn through this vaccine-enthusiastic population in fairly short order — meaning “the supply-demand shift for the vaccine will happen earlier than expected — as early as the end of April — and before the nation reaches the 70-90% threshold for achieving herd immunity.”

Vaccination rates will then slow, and Surgo’s projections show that if what Americans now say about their preferred timelines for getting vaccinated is true — “as soon as it’s available,” “in three months,” “in a year,” “don’t know” and “would not get vaccinated” — overall U.S. coverage will plateau around 52 percent of the population by July. When combined with people who have already been infected, the total immunity rate may hit 65 percent by then, according to Surgo — still not high enough for herd immunity.

To reach that threshold, Surgo estimates the U.S. will have to flip as many as a third of American adults from “no”s or “not sure”s to “yes”es — and/or start vaccinating children en masse. That won’t be easy, especially if COVID-19 cases plummet amid warming weather and widening immunity, and many reluctant Americans say “why bother?” as a result. (In Israel, the world’s leading vaccinator, coverage hit 50 percent one month ago and has increased only incrementally since then.)

To keep its vaccination campaign chugging along, the U.S. will have to stop relying on demand and start strengthening its persuasion tactics and its delivery systems, particularly in underserved communities. It will have to start meeting people where they are.

Right now, it’s impossible to say precisely how the Johnson & Johnson pause will play out. Some experts are worried it will increase overall vaccine hesitancy; others predict a wash, as those eager to get vaccinated either follow updated J&J guidance or shift to a different vaccine, with long-term trust actually rising because the government chose to be transparent.

Either way, any American who wants a shot will soon find it all too easy to get one — and the U.S. will find it harder and harder to give them out.

Expect talk about the need for booster shots to pick up speed when the vaccine-willing population is exhausted. Once the vaccine reluctant population has been groomed over hard- we are not there yet but when we do get there- the marketing folks know that it may be easier to get the "pro-vaccine" population to to take another shot than it is easy to get the hard core reluctant to take their first one.
 
Expect talk about the need for booster shots to pick up speed when the vaccine-willing population is exhausted. Once the vaccine reluctant population has been groomed over hard- we are not there yet but when we do get there- the marketing folks know that it may be easier to get the "pro-vaccine" population to to take another shot than it is easy to get the hard core reluctant to take their first one.

They are well ahead of you...

Coronavirus: Third vaccine dose likely needed within a year of receiving both shots, says Pfizer CEO
CEO Albert Bourla said that residents would also likely need to get the vaccinations annually.
https://scroll.in/latest/992436/cor...-year-of-receiving-both-shots-says-pfizer-ceo
 
Long overdue... the Trump administration should have done this.

US setting up $1.7B national network to track virus variants
https://www.wral.com/us-setting-up-1-7b-national-network-to-track-virus-variants/19630385/

The U.S. is setting up a $1.7 billion national network to identify and track worrisome coronavirus mutations whose spread could trigger another pandemic wave, the Biden administration announced Friday.

White House officials unveiled a strategy that features three components: a major funding boost for the Centers for Disease Control and Prevention and state health departments to ramp up coronavirus gene-mapping; the creation of six “centers of excellence” partnerships with universities to conduct research and develop technologies for gene-based surveillance of pathogens; and building a data system to better share and analyze information on emerging disease threats, so knowledge can be turned into action.

“Even as we accelerate our efforts to get shots into arms, more dangerous variants are growing, causing increases in cases in people without immunity,” White House coronavirus adviser Andy Slavitt told reporters. That “requires us to intensify our efforts to quickly test for and find the genetic sequence of the virus as it spreads.”

The new effort relies on money approved by Congress as part of President Joe Biden's coronavirus relief package to break what experts say is a feast-or-famine cycle in U.S. preparedness for disease threats. The coronavirus is only one example. Others pathogens have included Ebola and Zika, and respiratory viruses like SARS in 2002 and MERS in 2012, which did not become major problems in the United States. Typically, the government scrambles to counter a potential threat, but funding dries up when it recedes. The new genomic surveillance initiative aims to create a permanent infrastructure.

“It’s a transformative amount of money,” Mary Lee Watts, federal affairs director at the American Society for Microbiology, said in a recent interview. “It has the potential not only to get ahead of the current crisis, but it is going to help us in the future. This is a program that has been underfunded for years.”

The Biden administration's move comes as a variant known as B117, which first emerged in the United Kingdom, has become the predominant strain in the U.S. In hard-hit Michigan, the more transmissible mutation accounts for more than half the cases, according to CDC data. That's also the case in Minnesota. Vaccines are effective against the so-called U.K. variant, but other mutations circulating around the globe have shown resistance to currently available vaccines.

CDC Director Dr. Rochelle Walensky said Friday the U.S. is now averaging nearly 70,000 new coronavirus cases daily, up from about 53,000 just four weeks ago. Hospitalizations have been trending higher, and deaths were up for the third day in a row. Along with relaxed restrictions on gatherings and indoor dining, the emergence of variants that spread more easily is part of the reason for the worsening trend.

“In order for us to even have the possibility of getting back to normal by the fall we need to massively scale up our genomic surveillance,” said Esther Krofah, who directs the Faster Cures initiative of the Milken Institute. “It's the insurance program that you need to have in place not just now, not just for COVID, but going forward for other pathogens of concern.”

Genomic sequencing essentially involves mapping the DNA of an organism, the key to its unique features. It’s done by high-tech machines that can cost from several hundred thousand dollars to $1 million or more. Technicians trained to run the machines and computing capacity to support the whole process add to costs. Another hurdle is getting local, state and federal labs all working together.

The CDC and collaborating labs were completing only 116 coronavirus gene sequences a week at the end of last year, according to the CDC's website. “We started in a hole," said Slavitt.

The White House says the weekly count is now about 29,000, but experts say in a large, diverse country like the U.S. those numbers need to be much higher to keep pace with potential changes to the virus. Viruses are highly efficient at spreading, developing mutations that enable them to keep reproducing.

White House officials said the government is releasing to states and territories an initial $240 million out of $1 billion allocated to expand genomic sequencing. Another $400 million will go to launch the six research partnerships with academic institutions, dubbed Centers of Excellence in Genomic Epidemiology. Finally, $300 million will go to set up the data sharing system, which is being called the National Bioinformatics Infrastructure.
 
https://www.axios.com/biden-obamas-...ial-f7412507-fafe-497e-96e7-d4adf7d3d22c.html
Biden and Obamas to star in COVID vaccination TV special
President Biden, former President Obama and Michelle Obama are joining a slew of stars for an NBC special this weekend that aims to raise awareness of COVID-19 vaccines, dispel myths and boost inoculation rates.

What to expect: In Sunday's "Roll Up Your Sleeves" special, hosted by NFL quarterback Russell Wilson and actor-singer Ciara, Biden will urge Americans to "beat the pandemic, protect loved ones and continue the road to recovery," according to a statement from NBC.

  • NBA greats Charles Barkley and Shaquille O'Neal will team up with former President Obama in the special, which airs Sunday at 7p.m. ET.
  • Former first lady Michelle Obama will be joined by Lin-Manuel Miranda, Faith Hill and Jennifer Lopez.
The big picture: The special comes as new polling shows Americans' confidence in the safety of Johnson & Johnson's coronavirus vaccine took a big dip this week after the pause in its use.
  • That's despite the risk of blood clots following the shot being extremely low, "if it exists at all," Axios' Caitlin Owens and Marisa Fernandez note.
Of note: The hour-long special will feature actor Matthew McConaughey interviewing Biden's chief medical adviser, Anthony Fauci, about separating "fact from fiction," per NBC's statement.
t_1484255990770_name_5877f22ce4b03735090bf921_1455589917779_yrd15k_t_1484255923538_640_360_400.gif
 
https://www.wsj.com/articles/march-hiring-surge-spanned-the-country-11618584819

March Hiring Surge Spanned the Country
U.S. payrolls increased in 49 states, with California, Texas and New York adding the most jobs

Hiring increased in 49 states across the country in March, with large states such as California, Texas and New York adding the most jobs, the Labor Department said Friday.

Employers in leisure and hospitality, including at restaurants, hotels and entertainment venues, accelerated hiring across the U.S. That allowed some of the hardest-hit states, such as Hawaii, to see strong job growth last month.

“Better health conditions and expanding reopenings will strengthen and widen the breadth of state labor market recoveries,” said Oren Klachkin, lead U.S. economist at Oxford Economics. “Fiscal stimulus will promote positive labor market dynamics through the health crisis’ final stages.”

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We are reaching the point where the demand for vaccines have dropped in many counties...

Too few people seeking shots at most Wake vaccination clinics
https://www.wral.com/coronavirus/to...ts-at-most-wake-vaccination-clinics/19637273/

Wake County has plenty of doses of coronavirus vaccine, but few people are signing up for their shots, officials said Tuesday.

At Wendell Community Park, for example, only 65 of 1,680 available vaccination appointments – just 3 percent – have been booked this week.

Dr. David Weber, an infectious disease expert with UNC Health, said people's reluctance to get vaccinated could prevent North Carolina and the U.S. from reaching herd immunity, where so few people can spread coronavirus that the virus dies out. The state or nation needs a vaccination rate of about 85 percent for herd immunity, he said.

"I'm concerned about that, that we will continue to immunize people, the numbers will go up, but we won't reach the magical number of 80 to 85 percent," Weber said. "If we have enough people unwilling to take the vaccine, it actually means we'll never reach true levels of protection."

Ryan Jury, who oversees Wake County's vaccination efforts, says the open appointments don't reflect hesitancy to getting shots. Rather, he said, it's an access issue.

"Currently, we have the ability to administer 30,000 vaccines per week. What we are trying to do is to promote availability to access throughout the community by opening more sites," Jury said.

Vaccination clinics in Raleigh, for example, have 58 percent of their appointment booked this week, with all 840 slots at Departure Drive in north Raleigh filled. The drive-thru clinic outside PNC Arena has about two-thirds of its appointments scheduled, while the clinics at Wake County Commons Building and the Wake County Public Health Center, both in east Raleigh, are both around 40 percent booked.

"We continue to look at our program to ensure that we offer evening hours and weekend hours and that we have access across the county, so that there are vaccine locations ... throughout the county for those who are willing to or interested, that they have access," Jury said.

The county plans to open more vaccination sites in the coming weeks, with a goal of having five to 10 spread across the county.
 
We are reaching the point where the demand for vaccines have dropped in many counties...

Too few people seeking shots at most Wake vaccination clinics
https://www.wral.com/coronavirus/to...ts-at-most-wake-vaccination-clinics/19637273/

Wake County has plenty of doses of coronavirus vaccine, but few people are signing up for their shots, officials said Tuesday.

At Wendell Community Park, for example, only 65 of 1,680 available vaccination appointments – just 3 percent – have been booked this week.

Dr. David Weber, an infectious disease expert with UNC Health, said people's reluctance to get vaccinated could prevent North Carolina and the U.S. from reaching herd immunity, where so few people can spread coronavirus that the virus dies out. The state or nation needs a vaccination rate of about 85 percent for herd immunity, he said.

"I'm concerned about that, that we will continue to immunize people, the numbers will go up, but we won't reach the magical number of 80 to 85 percent," Weber said. "If we have enough people unwilling to take the vaccine, it actually means we'll never reach true levels of protection."

Ryan Jury, who oversees Wake County's vaccination efforts, says the open appointments don't reflect hesitancy to getting shots. Rather, he said, it's an access issue.

"Currently, we have the ability to administer 30,000 vaccines per week. What we are trying to do is to promote availability to access throughout the community by opening more sites," Jury said.

Vaccination clinics in Raleigh, for example, have 58 percent of their appointment booked this week, with all 840 slots at Departure Drive in north Raleigh filled. The drive-thru clinic outside PNC Arena has about two-thirds of its appointments scheduled, while the clinics at Wake County Commons Building and the Wake County Public Health Center, both in east Raleigh, are both around 40 percent booked.

"We continue to look at our program to ensure that we offer evening hours and weekend hours and that we have access across the county, so that there are vaccine locations ... throughout the county for those who are willing to or interested, that they have access," Jury said.

The county plans to open more vaccination sites in the coming weeks, with a goal of having five to 10 spread across the county.

Time for tranquilizer darts
 
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