Quote from riskarb:
I don't understand your comments about atm > otm commission, but I assume you're referring to a larger bid-ask spread in the straddle, which are often more competitive when calculating premium/spread -- premium received over bid-ask spread.
Straddles are preferable. You're selling downside gamma[slope] in the straddle, which reduces delta speed as the trade moves away from neutrality. The strangle-gamma is upside-sloping, increasing the delta's speed as it trades away from neutrality -- this can be referred to as "cheap gamma" due to it's acceleration as the underlying trades to either strike at -strike vol. Vol-smile is for another post, but otm options on individual equity options often exhibit *net* -skew when accounting for the blended, average vols received.
Straddles carry their max greek sensitivity when trading neutral[delta]; strangles carry the maximum when trading at either strike, which isn't what you're looking for when earning from volatility, stat[gamma-artifact] or implied. Why carry deltas when you're selling vegas?
Short combos are often traded to isolate the vega or theta[-gamma] distro-peaks, both of which occur at delta neutrality with the short straddle. You're receiving a potentially broader PnL distro, but with inferior curvature attributes with a strangle.
In practical terms, the straddle is preferable if you're trading a short gamma basket and you'd prefer to maintain unimodal gamma. They allow the trader to maintain +theta into any short gamma butterfly conversions. The strangle seller must either convert to a long gamma butterfly[body purchase] and invert modality, or trade a short gamma condor in lieu of a butterfly.
In the context of the question at-hand, the straddle is preferable for isolating vega, gamma and carries a superior risk-reward.