I'll throw in a plug for Chicago.
Having worked and lived in CA, DC, TX, and NYC, Chicago's the best balance I've found:
Big city venues and features - and unlike NYC it's clean
Lots of different city neighborhoods and suburbs to choose from depending on your preferred lifestyle and surroundings
State income tax is 3% flat
Sales tax about 6%
No personal property taxes
Costs about $70/yr to register your car (some townships hit you for something extra though for village registration)
Good health insurance policy for a single self-employed about $150-175/month (family about $450/month)
Much better bang for the buck on real estate than CA or NY/NJ - property taxes fluctuate though, but where I'm at I pay about $4500/yr on a half million dollar house that would easily cost $800K-1M in NYC/NJ or CA
Downside with kids is if you live downtown, you'll probably at least think about sending the kids to private school rather than public school. But as an alternative you can live in an upscale suburb with a good school district and still only be 20 minutes from downtown by train or car (non-rush hour).
Got to deal with winter, but they haven't been as bad as NY/NJ has gotten lately and it's a lot easier to deal with cold than triple digit heat. Part of the summer is a little hot and humid, but nothing like Texas and certainly no 110+ degree days like you'll get in Vegas. And you can always go down to the beach on Lake Michigan to cool off and watch the bikinis.
Last week was kind of hot and sticky, but it's a lot better this week - it's August and today was 75 and we're sleeping with the windows open at night with temp in the 60s.
All in all, not a bad balance of factors - at least IMO