I stumbled across this thread by accident, and looking at the subject line I realised I'm kind of trespassing, but its an interesting subject.
I don't trade spreads any more (though I do have some relative value signals in my univariate system), but I used to, mainly in fixed income futures (both intra market in STIR, and inter market in both bonds and rates) and also swaps. I thought I'd just add my view.
I see spread trading as sitting on a continoum between pure relative value and pure directional trading.
On the one side you've got adjacent intra market spreads. Strong relationships. Very high correlation. Very low natural risk. Lots of leverage needed. Negative skew type returns, higher Sharpe, more tail risk. Divergences from the mean probably last for less time, so you have shorter holding periods and probably higher trading costs.
Looking more like directional risk you've got inter market spreads. Of course there is a spectrum here as well. The crack spread is stronger than the inter market spreads in bonds, bonds stronger than equities. Weaker relationships. Lower correlation. Less leverage needed. Less like negative skew, lower Sharpe, protracted drawdowns rather than tail risk when divergences happen. Divergences are longer, probably lower trading costs.
The inter market spread relationships are sometimes less obvious. So in bonds for example yields across countries show some weak cointegration; the futures prices don't. Wackier and perhaps non linear hedge ratios are the name of the game. Wheras a 1:1 spread in STIR is naturally a yield differential (although you might want to vol adjust especially if you're at the front of the curve).
Not saying one extreme or the other is better, but clearly its horses for courses (or you could do both).
Best of luck to you and your clients.
Fine Print: "Generally Speaking"
Definitely. Inter-market Spreads have more co-integration issues from a statistical standpoint, and from a capitalization standpoint the SPAN margin credits are typically less generous. I tell my clients that I personally will not consider an inter-market spread with less than a 93 percent positive statistical correlation over the past 2 years ( OTR ).
Another consideration is execution - with inter-market spreads, you will either have to leg them manually or use some sort of spread execution software tool. I cover this topic with my clients. The main theme here is to not get "cute".
If you understand the risks and have modeled the trade correctly, I have had some clients do very well with inter-market spreads. I also have some clients with some ridiculously good performance metrics who don't bother with them - they're quite happy with the intra-commodity spread opportunities. It seems that some clients have a greater attraction to them than other clients. YMMV