I'll give you a quick virology lesson without going into too much detail.
- SARS-CoV is different than SARS-CoV-2 (aka Covid-19) although they both are coronaviruses.
SARS-CoV-2 and SARS-CoV use the same host cell receptor. It also found that, for both viruses, the viral proteins used for host cell entry bind to the receptor with the same tightness (affinity).
Another
recent study compared the specific area of the viral protein that’s responsible for binding to the host cell receptor. Researchers observed that the receptor binding site of SARS-CoV-2 binds to the host cell receptor with a
higher affinity than that of SARS-CoV.
The difference that caused the medical treatments success rate when comparing the two is the encoding protein Orf8. Covid-19 evolved...getting smarter by
removing/
adding nucleotides (playing amino acid switch) on the Orf8 component.
Thus, it lessens the effectiveness of
chloroquine against SARS-CoV-2 (Covid-19). Therefore, Covid-19 is one smart and very nasty virus...interfering with our immune responses and causing higher hypoxia in comparison to SARS-CoV.
If indeed SARS-CoV-2 has a higher binding affinity for its host cell receptor, this could also explain why it appears to be transmitted more easily than SARS-CoV.
Simply, some medical treatments like
chloroquine are suitable treatments for SARS-CoV back in 2003 but have LESS success rates in preventing the binding of SARS-CoV-2 to host receptor sites in 2020 because coronaviruses easily evolved into a virus with better defenses as in better transmittable.
- SARS-CoV is deadlier than SARS-CoV-2 but the difference is that SARS-CoV was quickly contained whereas SARS-CoV-2 was not.
For what it is worth, you're now talking about Covid...in step with your thread title.
Whereas, if you wanted to talk about Vaccines and your anti-vaccine opinions...that's the title you should have used. Yet, now that you're venturing into the Fauci and the politics of Covid...be very careful...your thread could be moved into the Political thread section.
Sorry, another Anti-Vaccine Thread
You can either now begin discussions about Covid (the disease)
or continue with your anti-vaccine opinions and the anti-vaccine opinions of others that post misinformation/disinformation about vaccines...your choice.
Take care and thanks for the article because it open the door for the scientific aspects (molecular biology) of Covid-19 that impacts our health and explains why some medical treatments are more successful against other
prior coronaviruses.
wrbtrader