Quote from iuvius:
Some of my best trades have been near the end of the week. Big commissions for small theta.
If the underlying gets close to your option strike, you can close out the position, cut the loss, and call it a day (or even reopen the position in a new spot).
But over the weekend, all sorts of unpredictable things can happen. Remember that an IC is best for a sideways market, and after-hours gapping is, well, the opposite of sideways, with no chance to close your position and cut losses.
Personally, I wait until Monday morning. And save some for later in the week. You might discover some late bloomers.