I am currently running a GeForce 3 and the Matrox G450 dual monitor card. I had a few driver issues at first, but once I got that settled, its worked great (I had to reinstall the Nvidia drivers after the Matrox card was in). I am running XP. I don't know if you'll get the same results with the quad card. I considered going with the quad, but why spend 6 or 8 times as much for a quad when you can get the dual card for under $100 each? If I need to add screens I'll just add another G450.