Quote from CalScholar:
People playing at multiple tables usually play very tightly. A tight player with three games going simultaneously will still spend the majority of his/her time on the sidelines waiting for good cards. Once they're dealt a great hand, they'll play very aggressively in an attempt to maximize profits. If you spend enough time playing online poker, these players become very easy to spot.
When you spot a player as I just described, you'll notice a pattern to their playing. Once they have a great hand, they'll raise big pre-flop (5+ times the BB). The reasoning is simple: pocket Jacks or AK are great hands heads-up or against two opponents, but against a larger field they'll most likely get cracked.
But here's the good part. Such players develop an entitlement attitude and will almost always bet big on the flop, whether they made a hand or not. More often than not, they're going to miss, and a simple check raise can be quite profitable. A lot of great players avoid going up against tight opponents, which, IMO, is a big mistake. After all, tight players are the easiest to read.