Nontuberculous Mycobacteria

T

tango29

Anyone here have any experience themselves or with friends or family with this lovely infection?
Curious if so what treatment they followed and if anything worked to get rid of it. My wife has it in her lungs for about 3 years now. The initial treatment got it under control, but it never went away completely. It is kind of a bitch, she coughs a lot and has breathing issues occasionally. The treatments she is on helps, but she can't seem to beat it completely.
Thanks
 
poopy said:
I've only seen one case resolve w/o the z-pak trio. Manuka honey (the crazy strong one):

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9703798/

I think I have a bottle or two in the house (unopened) if you want I'll ship it out.
More...
Thank you, I will pass it on to my wife, she has a strong medical background and will understand the article more than me.
If she is up for trying I will let you know and very much appreciate the offer. I will look at the Amazon product also.
It sucks seeing her dealing with this, she is tougher than me when it comes to battling through this kind of thing. It is obviously wearing on her so I am willing to try something that Docs haven't offered at this point, but she has to be the one to make the call.
Again, thank you very much for the input and offer
 
tango29 said:
Anyone here have any experience themselves or with friends or family with this lovely infection?
Curious if so what treatment they followed and if anything worked to get rid of it. My wife has it in her lungs for about 3 years now. The initial treatment got it under control, but it never went away completely. It is kind of a bitch, she coughs a lot and has breathing issues occasionally. The treatments she is on helps, but she can't seem to beat it completely.
Thanks
More...

I'm sorry to hear about this. It's brutal to have a loved-one in an unhealthy condition.

Some additional ideas based on what I've read in peer-reviewed medical literature:

Could discuss with the treating physician the potential use of N-acetylcysteine (NAC) to decrease mucus viscosity / facilitate clearance and to support glutathione production. Also, Rosita cod liver oil, ~1 tsp/d, for its immuno-supportive retinol & vitD and its anti-inflam DHA.

Consider titrating 25OHD from sunlight, food, and supplements to 40-45 ng/mL in blood -- the peak of the mortality rate inverted U-curve seems to be there, but only when vits A and K2 are also optimized. Consider eliminating all sugars (fructose/fruits, sucrose, glucose, any -ose) from food intake.

As a wild guess: if there is some evidence of Myeloid-derived suppressor cells (MDSC) T cell suppression, could consider taking supplemental L-Arginine, L-tryptophan, and glycine. I read that MDSC severely reduces these essentials as well as glutathione.

References:
Ontogeny of myeloid cells
De Kleer, et al., 2014, Frontiers in immunology, vol. 5, article 423

Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity
Veglia, et al., 2021, Nature reviews. Immunology, vol. 21, issue 8, p. 485-498

Myeloid-Derived Suppressor Cells: A Propitious Road to Clinic
Grover, et al., 2021, Cancer discovery, vol. 11, issue 11, p. 2693-2706​
 
EllisWyatt said:
I'm sorry to hear about this. It's brutal to have a loved-one in an unhealthy condition.

Some additional ideas based on what I've read in peer-reviewed medical literature:

Could discuss with the treating physician the potential use of N-acetylcysteine (NAC) to decrease mucus viscosity / facilitate clearance and to support glutathione production. Also, Rosita cod liver oil, ~1 tsp/d, for its immuno-supportive retinol & vitD and its anti-inflam DHA.

Consider titrating 25OHD from sunlight, food, and supplements to 40-45 ng/mL in blood -- the peak of the mortality rate inverted U-curve seems to be there, but only when vits A and K2 are also optimized. Consider eliminating all sugars (fructose/fruits, sucrose, glucose, any -ose) from food intake.

As a wild guess: if there is some evidence of Myeloid-derived suppressor cells (MDSC) T cell suppression, could consider taking supplemental L-Arginine, L-tryptophan, and glycine. I read that MDSC severely reduces these essentials as well as glutathione.

References:
Ontogeny of myeloid cells
De Kleer, et al., 2014, Frontiers in immunology, vol. 5, article 423

Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity
Veglia, et al., 2021, Nature reviews. Immunology, vol. 21, issue 8, p. 485-498

Myeloid-Derived Suppressor Cells: A Propitious Road to Clinic
Grover, et al., 2021, Cancer discovery, vol. 11, issue 11, p. 2693-2706​
More...
Thank you, I will look into this also, and I'll have my wife read these references also.
 
poopy said:
I've only seen one case resolve w/o the z-pak trio. Manuka honey (the crazy strong one):

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9703798/

I think I have a bottle or two in the house (unopened) if you want I'll ship it out.
More...

Wife read through and is going to bring the article up to whoever who her new pulmonologist is, her hospital group has gone through 3 and just hired a new group. Currently she has been using an infectious disease doc who she likes and has been great.
One problem for her is azithromycin doesn't work for her for anything. I forget which drug she mentioned they had moved to, but she is going to ask about it in combination with the honey, and at least give it a try.
She very much appreciates the input and is going through the other articles also.
 
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