New Study Suggests Asymptomatic COVID Patients Aren't "Driver Of Transmission"

[Wallet]

Thanks in part to a massive investment in research by the British government, a lot of interesting data has come out of the UK, including a study which supposedly found evidence that immunity to COVID 'degrades' in the months after infection. Now, other studies have come to seemingly contradictory conclusions. It's just another reminder how fraught and complicated the process of study and research can be during an unprecedented pandemic.

It should also be a reminder, particularly as all the world's top COVID-vaccine manufacturers reassure the public that their vaccines will work against the more infectious mutated strains allegedly discovered in the UK and South Africa, among other places, that the leading scientific and public health authorities aren't always 100% certain when it comes to - as they like to call it - "the science".

And in yet another reminder of this principle, the American Medical Association's JAMA Network Open journal has published new research from a government-backed study that appears to offer new evidence that asymptomatic spread of COVID-19 may be significantly lower than previously thought.

Some members of the public might remember all the way back in February and January when public officials first speculated that mass mask-wearing might not be that helpful unless individuals were actually sick. They famously back-tracked on that, and - for that, and other reasons - decided that we should all wear masks, and that lockdowns were more or less the best solution to the problem, even as millions of Americans continued to flout the new "rules" daily.

More at.....

https://www.zerohedge.com/geopoliti...atic-covid-patients-arent-driver-transmission

 

[Cuddles]

zerohedge lol.

quote the original sources OP, you don't want ppl laughing at you.

 

[Bugenhagen]

Dumbass still quoting the Kremlin's arrangement of news. Aiding to the enemy's interests gets you shot in wartime.

Wallet has been warned about this too many times, he has no brain and no dignity.

 

[jem]

comment on the content not the messenger...
if you don't want every thinking person to view you as a moron...

everytime you do this same "lol" bs... here4dnc.

zerohedge lol.

quote the original sources OP, you don't want ppl laughing at you.

 

[jem]

very interesting article / study...

2 points the fear mongers... should review...



a.
It’s also unclear to what extent people with no symptoms transmit SARS-CoV-2. The only test for live virus is viral culture. PCR and lateral flow tests do not distinguish live virus. No test of infection or infectiousness is currently available for routine use.678 As things stand, a person who tests positive with any kind of test may or may not have an active infection with live virus, and may or may not be infectious.9

The relations between viral load, viral shedding, infection, infectiousness, and duration of infectiousness are not well understood. In a recent systematic review, no study was able to culture live virus from symptomatic participants after the ninth day of illness, despite persistently high viral loads in quantitative PCR diagnostic tests. However, cycle threshold (Ct) values from PCR tests are not direct measures of viral load and are subject to error.10

While viral load seems to be similar in people with and without symptoms, the presence of RNA does not necessarily represent transmissible live virus. The duration of viral RNA shedding (interval between first and last positive PCR result for any sample) is shorter in people who remain asymptomatic, so they are probably less infectious than people who develop symptoms.11



b. The transmission rates to contacts within a specific group (secondary attack rate) may be 3-25 times lower for people who are asymptomatic than for those with symptoms.1121415 A city-wide prevalence study of almost 10 million people in Wuhan found no evidence of asymptomatic transmission.16 Coughing, which is a prominent symptom of covid-19, may result in far more viral particles being shed than talking and breathing, so people with symptomatic infections are more contagious, irrespective of close contact.17 On the other hand, asymptomatic and presymptomatic people may have more contacts than symptomatic people (who are isolating), underlining the importance of hand washing and social distancing measures for everyone.

 

[Wallet]

https://www.bmj.com/content/371/bmj.m4851

https://www.zerohedge.com/geopoliti...atic-covid-patients-arent-driver-transmission

Creditable sources are reposted on Zerohedge and somehow that magically transforms them into Russian propaganda?......

At least that’s the spin by some foreign internet trolls......

And I’m supposed to be concerned about their butthurt....c’est la vie

 

[Cuddles]

https://www.bmj.com/content/371/bmj.m4851

https://www.zerohedge.com/geopoliti...atic-covid-patients-arent-driver-transmission

Creditable sources are reposted on Zerohedge and somehow that magically transforms them into Russian propaganda?......

At least that’s the spin by some foreign internet trolls......

And I’m supposed to be concerned about their butthurt....c’est la vie

Good, now let's take a look at what the conclusions are:

Earlier estimates that 80% of infections are asymptomatic were too high and have since been revised down to between 17% and 20% of people with infections.12 Studies estimating this proportion are limited by heterogeneity in case definitions, incomplete symptom assessment, and inadequate retrospective and prospective follow-up of symptoms, however.3 Around 49% of people initially defined as asymptomatic go on to develop symptoms.45

The relations between viral load, viral shedding, infection, infectiousness, and duration of infectiousness are not well understood. In a recent systematic review, no study was able to culture live virus from symptomatic participants after the ninth day of illness, despite persistently high viral loads in quantitative PCR diagnostic tests. However, cycle threshold (Ct) values from PCR tests are not direct measures of viral load and are subject to error.10

While viral load seems to be similar in people with and without symptoms, the presence of RNA does not necessarily represent transmissible live virus. The duration of viral RNA shedding (interval between first and last positive PCR result for any sample) is shorter in people who remain asymptomatic, so they are probably less infectious than people who develop symptoms.11

Viral culture studies suggest that people with SARS-CoV-2 can become infectious one to two days before the onset of symptoms and continue to be infectious up to seven days thereafter; viable virus is relatively short lived.7 Symptomatic and presymptomatic transmission have a greater role in the spread of SARS-CoV-2 than truly asymptomatic transmission.121213

The transmission rates to contacts within a specific group (secondary attack rate) may be 3-25 times lower for people who are asymptomatic than for those with symptoms.1121415 A city-wide prevalence study of almost 10 million people in Wuhan found no evidence of asymptomatic transmission.16 Coughing, which is a prominent symptom of covid-19, may result in far more viral particles being shed than talking and breathing, so people with symptomatic infections are more contagious, irrespective of close contact.17 On the other hand, asymptomatic and presymptomatic people may have more contacts than symptomatic people (who are isolating), underlining the importance of hand washing and social distancing measures for everyone.




So, we can conclude, that unlike the ZH opinion piece which aims to say that asymptomatic transmission isn't a 'driver for transmission' (whatever that means), the study suggests that asymptomatic transmission evidence is scarce yet inconclusive with some studies suggesting lower than initially thought transmission while others finding scarce proof, and that presymptomatic transmission (which ipso facto is asymptomatic until a person develops symptoms) is of underlying importance and thus a "driver". Sorry, OP, I too which I could read the future and determine if I would become symptomatic once infected, or become a billionaire knowing the markets.

 

[Bugenhagen]

He won't ever get providing links to an enemy site, no grasp of how things are measured by engines.. And nobody wants to give them clicks as that two promotes them, it's like voting for them.

Also, and this must be the third or fourth time, he is not educated enough to grasp the difference between what he intuitively thinks of asymptomatic and what medicine classes it, not mildly and not pre.

 

[Cuddles]

Good, now let's take a look at what the conclusions are:

Earlier estimates that 80% of infections are asymptomatic were too high and have since been revised down to between 17% and 20% of people with infections.12 Studies estimating this proportion are limited by heterogeneity in case definitions, incomplete symptom assessment, and inadequate retrospective and prospective follow-up of symptoms, however.3 Around 49% of people initially defined as asymptomatic go on to develop symptoms.45

The relations between viral load, viral shedding, infection, infectiousness, and duration of infectiousness are not well understood. In a recent systematic review, no study was able to culture live virus from symptomatic participants after the ninth day of illness, despite persistently high viral loads in quantitative PCR diagnostic tests. However, cycle threshold (Ct) values from PCR tests are not direct measures of viral load and are subject to error.10

While viral load seems to be similar in people with and without symptoms, the presence of RNA does not necessarily represent transmissible live virus. The duration of viral RNA shedding (interval between first and last positive PCR result for any sample) is shorter in people who remain asymptomatic, so they are probably less infectious than people who develop symptoms.11

Viral culture studies suggest that people with SARS-CoV-2 can become infectious one to two days before the onset of symptoms and continue to be infectious up to seven days thereafter; viable virus is relatively short lived.7 Symptomatic and presymptomatic transmission have a greater role in the spread of SARS-CoV-2 than truly asymptomatic transmission.121213

The transmission rates to contacts within a specific group (secondary attack rate) may be 3-25 times lower for people who are asymptomatic than for those with symptoms.1121415 A city-wide prevalence study of almost 10 million people in Wuhan found no evidence of asymptomatic transmission.16 Coughing, which is a prominent symptom of covid-19, may result in far more viral particles being shed than talking and breathing, so people with symptomatic infections are more contagious, irrespective of close contact.17 On the other hand, asymptomatic and presymptomatic people may have more contacts than symptomatic people (who are isolating), underlining the importance of hand washing and social distancing measures for everyone.




So, we can conclude, that unlike the ZH opinion piece which aims to say that asymptomatic transmission isn't a 'driver for transmission' (whatever that means), the study suggests that asymptomatic transmission evidence is scarce yet inconclusive with some studies suggesting lower than initially thought transmission while others finding scarce proof, and that presymptomatic transmission (which ipso facto is asymptomatic until a person develops symptoms) is of underlying importance and thus a "driver". Sorry, OP, I too which I could read the future and determine if I would become symptomatic once infected, or become a billionaire knowing the markets.

*wish