Personally, Yes, but they did it on open outcry floors and one lost it failing to make the transition to electronic. He makes the possibly biased point that he has never heard of anyone doing that from home, from a prop office maybe, but never from home. Anecdotally, many more.
Most (but not in any way all) of the big fortunes attributable stocks are actually from sale of businesses or from being the market clueless buy and hold shop floor guy whose stock was the one in a million that made people rich from buying and holding, rather than the those that made paupers of those who held on.
Others may have a very different circle of acquantence/experience to mine. I am counting pure trading and excluding hedgies and Plenty of people on USD1m+ in sales, research and trading in broking.