The VIX manipulated? You don't say!?
An index calculated on OTM, wide spread bid/ask, options that are less liquid than the average is begging to be manipulated. Similarly, /VX futures can influence /ES futures which can then influence S&P. Not sure anyone has enough capital to clear multiple levels of the SPY limit book. Some do for the /ES book during certain times of day. The /VX book? a million bucks could cause a flash crash or spike if done at the right time. Would probably not be a profitable trade though.
Try this: Plot VIX and SPYIX on a chart, then add a correlation (VIX/SPYIX) indicator with a period of 2 or 3 (short yes I know). Throw another corr indicator on there for SPYIX/SPY if you're feeling curious. Now observe what you see and then ask yourself which is a more reliable measure.
Don't bother trying to create a strategy with this though, the profit opportunity was much been arbitraged away over the last year or so.