If you do it manually, I recommend finding a few micro-caps that look "solid" to reduce the risk of a big loss. Basically, find something you wouldn't mind investing it and trade around your position without going short.
I trade about 500 low-volume stocks but I upload my limit orders overnight so I am not a "real" market maker. If you get stuck with a position in a thinly-traded stock, it's really hard to get out - the spreads can be as wide as 10-20% so be prepared for occasional big losses and limit your positions. Of course, the wide spreads is why it's "easy" to make decent profits (with a smallish account).