A retail trader doesn't have much choice in the SPX options if they want to sell premium, essentially you have to do IC's on the SPX you don't have the margin to sell strangles. On the ES the margin is so much lower you can just sell strangles/straddles...less commission overall and easier to get in and out. If you want to just buy options or debit spreads then either is fine. The reason I prefer ES options (I'm strictly retail) is that I can trade them nights and Sundays also can easily buy the cash ES to hedge if necessary.