If you think about what they are saying...
We have had natural imprints from this virus and other coronaviruses... hence why many of us had mild or asymptomatic responses. ...
The vaccinated may have now created a new imprint... and this imprint could be the high water mark for your ability to fight variants....
https://www.statnews.com/2021/04/16...etter-some-experts-worry-they-could-be-worse/
....
In the case of Covid, some scientists are concerned that the immune system’s reaction to the vaccines being deployed now could leave an indelible imprint, and that next-generation products, updated in response to emerging variants of the SARS-CoV-2, won’t confer as much protection.
That imprint can be helpful. In the 2009 H1N1 flu pandemic, elderly adults were protected by immune responses they’d generated more than half a century earlier, in childhood, through encounters with a related virus. But it can also interfere with your body’s ability to mount responses against strains that have evolved from the one you were first exposed to.
In the case of Covid, some scientists are concerned that the immune system’s reaction to the vaccines being deployed now could leave an indelible imprint, and that next-generation products, updated in response to emerging variants of the SARS-CoV-2, won’t confer as much protection.
Michael Worobey, who was been involved in groundbreaking research on imprinting with influenza, said he worries the responses to first-generation Covid-19 vaccines will prove to be “a high-water mark” for people’s immune responses to these inoculations.
“I do think it’s something that we need to be thinking about,” Worobey, a professor of evolutionary biology at the University of Arizona, told STAT. “We might actually see lower efficacy five years from now, if people are still locked into recalling the response to the first [SARS-2] antigen that they saw.”
Sarah Cobey, an associate professor of computational biology at the University of Chicago, shares his worry. “As long as we have competition between old antibody responses and new antibody responses … then it seems like exactly the right sort of environment to see these phenomena,” Cobey said.
“I can’t think of a reason that should be restricted to influenza,” she added.
Not everyone in the conversation is convinced there will be a problem, though.
...
much more at link...
We have had natural imprints from this virus and other coronaviruses... hence why many of us had mild or asymptomatic responses. ...
The vaccinated may have now created a new imprint... and this imprint could be the high water mark for your ability to fight variants....
https://www.statnews.com/2021/04/16...etter-some-experts-worry-they-could-be-worse/
....
In the case of Covid, some scientists are concerned that the immune system’s reaction to the vaccines being deployed now could leave an indelible imprint, and that next-generation products, updated in response to emerging variants of the SARS-CoV-2, won’t confer as much protection.
That imprint can be helpful. In the 2009 H1N1 flu pandemic, elderly adults were protected by immune responses they’d generated more than half a century earlier, in childhood, through encounters with a related virus. But it can also interfere with your body’s ability to mount responses against strains that have evolved from the one you were first exposed to.
In the case of Covid, some scientists are concerned that the immune system’s reaction to the vaccines being deployed now could leave an indelible imprint, and that next-generation products, updated in response to emerging variants of the SARS-CoV-2, won’t confer as much protection.
Michael Worobey, who was been involved in groundbreaking research on imprinting with influenza, said he worries the responses to first-generation Covid-19 vaccines will prove to be “a high-water mark” for people’s immune responses to these inoculations.
“I do think it’s something that we need to be thinking about,” Worobey, a professor of evolutionary biology at the University of Arizona, told STAT. “We might actually see lower efficacy five years from now, if people are still locked into recalling the response to the first [SARS-2] antigen that they saw.”
Sarah Cobey, an associate professor of computational biology at the University of Chicago, shares his worry. “As long as we have competition between old antibody responses and new antibody responses … then it seems like exactly the right sort of environment to see these phenomena,” Cobey said.
“I can’t think of a reason that should be restricted to influenza,” she added.
Not everyone in the conversation is convinced there will be a problem, though.
...
much more at link...
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