If anyone you care about has severe refractory ('untreatable') depression problems, this is the single most important thing you'll ever read. This is what antibiotics are to pneumonia, and what insulin is to diabetes. (Two other priceless gifts to humanity from people of Jewish ethnicity.)
It will sound crazy. It will sound ridiculous, even impossible... but every word is true. I'll even post a poll to watch how the majority of common fools will reject our scientific discoveries outright. If my knowledge was common knowledge (and it will be, inevitably, within the next 10-20 years.... At least in free societies, which may exclude the new Amerika.) suicide rates would PLUMMET. Incurable depression is now, in most cases, easily cured. THIS is undeniably, THE FUTURE of refractory depression treatment.
I am one of the few who know.
Here is the simplest possible summary, in layman's terms. I had to figure out all this out for myself, getting zero help from all the fucking worthless medical professionals who treated me....:
Everybody in the world has naturally occurring chemicals in their brain called endorphins. Endorphins are nearly identical to (narcotic) opiates like Morphine & heroin, but especially oxycodone. Believe it or not, your own body's endorphins are 48 times more powerful than heroin. We all need endorphins to regulate mood, and keep from getting intolerably depressed. Some people, like myself, have an endorphin deficiency. This is a torturous, often fatal condition... but can be easily cured. We merely need to take endorphins (=opiates) from an external source to feel 'normal' like everyone else.
I don't have a drug problem, I have a drug solution. Oxycontin works, but a much safer opioid called buprenorphine is a preferable treatment for many reasons. http://www.naabt.org/buprenorphine_overview.cfm
Now comes the proof:
This is from the website of an actual American clinic with branches in three cities.
http://www.thepainmanagementcenter.com/english/buprenorphine/clinical.htm
"Underproduction or over-removal (severe re-uptake) of these endogenous opioids can be the cause of many psychiatric disorders ranging from Bipolar Personality disorders to major depressive disorders that often times manifest themselves in severe drug abuse.<b> Unbeknownst to them, these patients use opioid medications either illicit or pharmaceutical because they are compelled to attempt to replace the endorphins, dynorphins, and enkephalins (endogenous opioids) that naturally occur in their systems at insufficient levels."</b>
Want more proof? You got it:
Buprenorphine Treatment of Refractory Depression
J. Alexander Bodkin, MD, Gwen L. Zornberg, MD, Scott E. Lukas, PhD,
and Jonathan O. Cole, MD.
Journal of Clinical Psychopharmacology, 1995, 15, pp. 49-57
Abstract
Opiates were used to treat major depression until the mid-1950s. The advent of opioids with mixed agonist-antagonist or partial agonist activity, with reduced dependence and abuse liabilities, has made possible the reevaluation of opioids for this indication. This is of potential importance for the population of depressed patients who are unresponsive to or intolerant of conventional antidepressant agents. Ten subjects with treatment-refractory, unipolar, non-psychotic, major depression were treated with the opioid partial agonist buprenorphine in an open-label study. Three subjects were unable to tolerate more than two doses because of side-effects including malaise, nausea and dysphoria. The remaining seven completed 4 to 6 weeks of treatment and as a group showed clinically striking improvement in both subjective and objective measures of depression. Much of this improvement was observed by the end of 1 week of treatment and persisted throughout the trial. Four subjects achieved complete remission of symptoms by the end of the trial (Hamilton Rating Scale for Depression scores < 6), two were moderately improved, and one deteriorated. These findings suggest a possible role for buprenorphine in treating refractory depression.
Introduction
Throughout history, opium and its derivatives have had an important role in the pharmacologic treatment of various behavioral disorders and by 1850 were considered to be specific treatments for melancholia (1). At the turn of the century, the eminent authority Emil Kraepelin recommended tincture of opium for the acute treatment of agitated depression(2). This use of opium and its derivatives continued to be recommended in psychiatric textbooks until as recently as 1956(3). However, before the development of modern methods of treatment evaluation, opiate treatment was replaced by somatic treatments such as electroconvulsive therapy and later by monoamine oxidase inhibitors and tricyclic antidepressants. These proved to be effective treatments that lacked the opiates' potential for abuse...Thus, the historically recognized antidepressant properties of the opiates have, with a few exceptions(4-8), received little empirical evaluation.
Currently used antidepressants, all of which act on monoaminergic systems, are neither universally effective nor free from adverse effects of their own(9). For the benefit of patients unresponsive to or intolerant of these agents, who may constitute 10 to 30% of the population of patients with major depression(10), alternative drug treatments need to be evaluated. Now, with the development of opioid partial agonist and mixed agonist-antagonist drugs exhibiting much reduced abuse and dependence liabilities,(11) it has become possible to safely evaluate the antidepressant efficacy of opioids.
Read the rest if you want the knowledge:
http://www.drugbuyers.com/freeboard/showflat.php?Cat=0&Number=196682
It will sound crazy. It will sound ridiculous, even impossible... but every word is true. I'll even post a poll to watch how the majority of common fools will reject our scientific discoveries outright. If my knowledge was common knowledge (and it will be, inevitably, within the next 10-20 years.... At least in free societies, which may exclude the new Amerika.) suicide rates would PLUMMET. Incurable depression is now, in most cases, easily cured. THIS is undeniably, THE FUTURE of refractory depression treatment.
I am one of the few who know.
Here is the simplest possible summary, in layman's terms. I had to figure out all this out for myself, getting zero help from all the fucking worthless medical professionals who treated me....:
Everybody in the world has naturally occurring chemicals in their brain called endorphins. Endorphins are nearly identical to (narcotic) opiates like Morphine & heroin, but especially oxycodone. Believe it or not, your own body's endorphins are 48 times more powerful than heroin. We all need endorphins to regulate mood, and keep from getting intolerably depressed. Some people, like myself, have an endorphin deficiency. This is a torturous, often fatal condition... but can be easily cured. We merely need to take endorphins (=opiates) from an external source to feel 'normal' like everyone else.
I don't have a drug problem, I have a drug solution. Oxycontin works, but a much safer opioid called buprenorphine is a preferable treatment for many reasons. http://www.naabt.org/buprenorphine_overview.cfm
Now comes the proof:
This is from the website of an actual American clinic with branches in three cities.
http://www.thepainmanagementcenter.com/english/buprenorphine/clinical.htm
"Underproduction or over-removal (severe re-uptake) of these endogenous opioids can be the cause of many psychiatric disorders ranging from Bipolar Personality disorders to major depressive disorders that often times manifest themselves in severe drug abuse.<b> Unbeknownst to them, these patients use opioid medications either illicit or pharmaceutical because they are compelled to attempt to replace the endorphins, dynorphins, and enkephalins (endogenous opioids) that naturally occur in their systems at insufficient levels."</b>
Want more proof? You got it:
Buprenorphine Treatment of Refractory Depression
J. Alexander Bodkin, MD, Gwen L. Zornberg, MD, Scott E. Lukas, PhD,
and Jonathan O. Cole, MD.
Journal of Clinical Psychopharmacology, 1995, 15, pp. 49-57
Abstract
Opiates were used to treat major depression until the mid-1950s. The advent of opioids with mixed agonist-antagonist or partial agonist activity, with reduced dependence and abuse liabilities, has made possible the reevaluation of opioids for this indication. This is of potential importance for the population of depressed patients who are unresponsive to or intolerant of conventional antidepressant agents. Ten subjects with treatment-refractory, unipolar, non-psychotic, major depression were treated with the opioid partial agonist buprenorphine in an open-label study. Three subjects were unable to tolerate more than two doses because of side-effects including malaise, nausea and dysphoria. The remaining seven completed 4 to 6 weeks of treatment and as a group showed clinically striking improvement in both subjective and objective measures of depression. Much of this improvement was observed by the end of 1 week of treatment and persisted throughout the trial. Four subjects achieved complete remission of symptoms by the end of the trial (Hamilton Rating Scale for Depression scores < 6), two were moderately improved, and one deteriorated. These findings suggest a possible role for buprenorphine in treating refractory depression.
Introduction
Throughout history, opium and its derivatives have had an important role in the pharmacologic treatment of various behavioral disorders and by 1850 were considered to be specific treatments for melancholia (1). At the turn of the century, the eminent authority Emil Kraepelin recommended tincture of opium for the acute treatment of agitated depression(2). This use of opium and its derivatives continued to be recommended in psychiatric textbooks until as recently as 1956(3). However, before the development of modern methods of treatment evaluation, opiate treatment was replaced by somatic treatments such as electroconvulsive therapy and later by monoamine oxidase inhibitors and tricyclic antidepressants. These proved to be effective treatments that lacked the opiates' potential for abuse...Thus, the historically recognized antidepressant properties of the opiates have, with a few exceptions(4-8), received little empirical evaluation.
Currently used antidepressants, all of which act on monoaminergic systems, are neither universally effective nor free from adverse effects of their own(9). For the benefit of patients unresponsive to or intolerant of these agents, who may constitute 10 to 30% of the population of patients with major depression(10), alternative drug treatments need to be evaluated. Now, with the development of opioid partial agonist and mixed agonist-antagonist drugs exhibiting much reduced abuse and dependence liabilities,(11) it has become possible to safely evaluate the antidepressant efficacy of opioids.
Read the rest if you want the knowledge:
http://www.drugbuyers.com/freeboard/showflat.php?Cat=0&Number=196682
