That's a truism. A smaller player should be able to get a much better return on risk/capital (I was walking from the subway today and saw a penny on the sidewalk - an arb!).
There really is no hard rule for this. You are measuring a lot of things at the same time - the effort needed, the capacity, the risk/reward, the information content (e.g. i might do a trade I've never done in small size if I am likely to learn something).
It's friday, do you feel like critiquing a thought process/trade?
I bought 11 straddles on SYNA yesterday @ 36 vol expiring April 18. Total vega position is 90

. Their was some company specific news released a few days ago + lower guidence for next quarter and the company plunged 15%. Realized vol and implied vol has dropped quite a bit since the news release but volume remains extremely high.
I'll be hedging the position every time the underlying moves 3% in one direction. I have a volume stop, so if the volume dries up to a certain threshold I'll exit otherwise I will continue to hold the position for as long as possible.
Current Historical Vol 10d is 95%
1 year Low Historical Vol 10d is 25% (this is my assumed worst case scenario)
Forecast realized Vol for life of option is 55% (this is forcasted using a simple regression with HV, IV, Volume and XLK Iv as the inputs)
So I am risking 11 vol points for a target of 19 points. My transaction Costs are $1 per hedge + minimal slippage on entering and exiting the trade.
What do you think about the process?
Also, should I be looking for thinner spreads and increase my number of trades? Or should I be looking for wider spreads and reduce the amount of times I trade. Here is a graph of the vols of SYNA.