Unless you are lucky, have good ability at predicting future underlying direction, or just want to gain somewhere around the risk-free rate, IMHO just throwing on spreads and/or short option trades for no other reason than the conventional wisdom of "more options expire OTM, than ITM, etc, etc..." is not going to get you very far.
A possible exception is to run lots of OPM and sell far OTM strikes, thereby hoping you get enough returns and fees to pad your retirement before the inevitable wipeout happens.
I haven't explored it much but I believe there is opportunity in trading volatility surface discrepancies. Options pricing models (and trading desks) are far from perfect and there exists volatility skew between months and strikes. I think this is (one) of the specialties of traders here like Des, sle, big short, others. Certainly, this type of trading will take much study.