Well, I almost never buy ITM premium (very rarely I'll use high-delta puts in lieu of a short on the outright), so yes, whenever I buy, they're OTM. And my ordinary target is 200% + on anything long.
On expiry Friday, sometimes I'll play penny options looking for a move across a strike. Had a 300% winner of this type last week....except I didn't have the margin left to exercise and could free it up--so I had to close during market hours rather than shorting and exercising. Ended up scratching it. A few months ago I did the same thing on MSFT....bought some expiring options for .04 and ended up shorting the shares and exercising for north of 1200%.
But the vast majority of my positions are base hits...not swinging for the fences. But at least a few days every week I will have orders fill rest until close that are just looking for very good prices on long shot options. Taking a rebate and not paying the spread vastly improves chances on these types of plays...and payout if they work.