When we talk about the 10 largest cities in the U.S. - we are actually talking about the 10 largest Metropolitan Areas as defined by the Census Bureau. These Metro areas represent a population of over 80 million people out of 326 million in the U.S. -- effectively if the U.S. used the popular vote for the presidency, candidates would only have to campaign in these metro areas plus a couple others (e.g. San Francisco) to lock in thresholds for victory. In fact politicians could entirely ignore 34 states in their campaigns and still easily reach a 50% threshold.
Voters in the biggest cities in the US are almost exactly balanced out by rural areas in terms of population and partisan composition.
16% of the U.S. population lives outside the nation's Metropolitan Statistical Areas. Rural America has voted 60% Republican. None of the 10 most rural states matter now.
16% of the U.S. population lives in the top 100 cities. They voted 63% Democratic in 2004.
The population of the top 50 cities (going as far down as Arlington, TX) is only 15% of the population of the United States.
The rest of the U.S., in suburbs, divide almost exactly equally between Republicans and Democrats.
Because of state-by-state winner-take-all laws, not mentioned, much less endorsed, in the Constitution. . .
Wisconsin Gov. Scott Walker in 2015 was correct when he said
"The nation as a whole is not going to elect the next president,"
“The presidential election will not be decided by all states, but rather just 12 of them.
Candidates have no reason to poll, visit, advertise, organize, campaign, or care about the voter concerns in the dozens of states where they are safely ahead or hopelessly behind.
With the end of the primaries, without the National Popular Vote bill in effect, the political relevance of 70% of all Americans was finished for the presidential election.
In the 2016 general election campaign
Over half (57%) of the campaign events were held in just 4 states (Florida, North Carolina, Pennsylvania, and Ohio).
Virtually all (94%) of the campaign events were in just 12 states (containing only 30% of the country's population).