Quote from AngusP:
Been looking at some payoff's based on placing a ratio backspread on 27th April. Best compromise I can find is a 5:3 using the 15 and 20 strikes. Prices shown are based on eod - you may have done better by legging in during the day, or worse of course.
I think this shows the dilemma. Price on the news would have needed to get above about 35 to show an immediate profit on a break to the upside. Otherwise you are left waiting for expiry above 19.47, and although the initial break on FDA approval may have been up to 35+, whether it would have stayed there until expiry is of course open to conjecture.
Given the break to the downside, there would have been a profit on Friday below about $11, and therefore a loss at all prices between 11 and 35. In reality I guess it may have been worse than that because an announcement that resulted in little movement would have lead to a volatility crush which would have widened those limits, and also given a greater loss in the 15 - 20 area.
I think you're using the wrong strikes. When the stock was around 15, the play would've been to sell the ATM's and buy 2x (or more) of the 12.5's or 10's. You may want to try those and see if the results would've been different.

