Biotech King, any of these catch your fancy?
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Neuron IMNN Phase 2 Topline Data; CNS Pharmaceuticals CNSP License Deal - Pre-Market Updates • BioPharmCatalyst
IMUNON, Inc. (NASDAQ: IMNN) announced the topline results from the Phase 2 OVATION 2 Study with IMNN-001 in patients with advanced ovarian cancer. Data reported a three-month improvement in PFS compared with standard-of-care alone, and an 11.1 month increase in median OS.
CNS Pharmaceuticals (NASDAQ: CNSP) entered into an exclusive license agreement with Cortice Biosciences for TPI 287, a potential blood-brain barrier permeable microtubule inhibitor for glioblastoma multiforme (GBM) treatment. CNS plans to engage with the FDA to design a potential registration study for TPI 287 in recurrent GBM, aiming to start in 2025.
Cognition Therapeutics (NASDAQ: CGTX) reported results from their Phase 2 study of CT1812 (SHINE) for treating Alzheimer’s disease. The drug showed a consistent trend in cognitive improvement compared to placebo across multiple measures. However, CT1812 did not achieve statistical significance on the first-ordered secondary efficacy endpoint.
Fractyl Health (NASDAQ: GUTS) announced that the FDA has granted Breakthrough Device Designation for their Revita System, designed to maintain weight loss after discontinuation of GLP-1 drugs. Revita is an outpatient endoscopic procedure that resurfaces the duodenal lining to potentially address a root cause of obesity and type 2 diabetes. Fractyl expects to report data from an open-label study in weight maintenance in Q4 2024 and a mid-point randomized analysis of the REMAIN-1 pivotal study in Q2 2025.
Evoke Pharma, Inc. (NASDAQ: EVOK) announced a 1-for-12 reverse stock split of the company’s common stock. The reverse stock split will become effective at 12:01 a.m. ET on August 1, 2024.
T2 Biosystems (NASDAQ: TTOO) reported second quarter 2024 results, with losses of $0.66 per share beating estimates by $0.31, but revenue of $1.95 million missing by $0.15 million or 7.05% below expectations. Canaccord Genuity maintained a Hold rating and raised the price target from $3 to $5.
Day One Biopharmaceuticals, Inc.(NASDAQ: DAWN) announced it has entered into a securities purchase agreement for an oversubscribed private placement of its securities for gross proceeds of approximately $175.0 million, before deducting placement agent fees and other expenses.
Intellia Therapeutics, Inc. (NASDAQ: NTLA) announced the authorization of its Clinical Trial Application (CTA) by the United Kingdom’s Medicine and Healthcare products Regulatory Agency (MHRA) to initiate a Phase 1/2 study evaluating NTLA-3001 for the treatment of alpha-1 antitrypsin deficiency (AATD)-associated lung disease. The trial is on track to dose the first patient in 2H 2024.”
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