If you mean by "true opening print" that the NYSE opens at a price and just stays there for the next 30 minutes . . . why would you want to trade that?
In OTC, you get waves and mini-waves of buying and selling; the ride can be nauseating but there's movement, and last I checked price movement was how ppl made money in this game hehe. Opening games on OTC can be extremely profitable, especially if you're not too greedy and capable of reversing your position quickly. The first 15 minutes remains the best time to initiate short positions, as retail still seems to buy the open, especially on news.
n Nasdaq,the fills are faster,the quotes are accurate,the spreads are tight,and there is more opportunity.Forget the fact that there are many MM's involved.If you trade based on price action and what the futures are doing,you should be ok.In the not so active stocks,you can try to ascertain which MM has most of the orders,and base your decisions on what he is doing.On the NYSE,all you're seeing is a bid,an offer,and mostly likely,an inaccurate size.