Disadvantages
The following issues might affect compatibility:
Microsoft Access MDE/ADE/ACCDE files Databases that have had their source code removed (such as .mde, .ade, and .accde files) cannot be moved between 32-bit and 64-bit editions of Office 2010. Such databases that are created by using 32-bit Office (any version) can be used only with 32-bit Office, and a database that is created on 64-bit Office can be used only on 64-bit Office.
ActiveX controls and COM add-ins ActiveX controls and add-in (COM) DLLs (dynamic link libraries) that were written for 32-bit Office will not work in a 64-bit process. As a result, Office 2010 64-bit solutions that try to load 32-bit ActiveX controls or DLLs will not work. Installations of 64-bit Office 2010 will run only 64-bit controls. Computers can have 64-bit and 32-bit controls installed, and Office 2010 64-bit can only run the 64-bit versions of the controls. The workaround for resolving these issues is to obtain 64-bit compatible controls and add-ins or to install Office 2010 32-bit (WOW).
In addition to controls that load into Office applications, there are also Web-based solutions that use ActiveX controls in Microsoft Internet Explorer. Office 2010 64-bit editions install some Office 32-bit client-side controls for supporting solutions in a 32-bit browser (the default browser on current 64-bit Windows systems). The Edit in Datasheet view functionality is not supported if you install 64-bit Office 2010. However, the functionality is available if you install 32-bit Office 2010.
In-place activation The following issues might occur if there is not a match between the bitness of Office 2010 and registered applications:
An OLE server might not instantiate in place and might fail to open if the application registered is not the same bitness as the version of Office installed. (For example, if the OLE Server application is 32-bit and the version of Office installed is 64-bit.)
Inserting an object into an Office 2010 application document might fail in cross-bitness scenarios. (For example if you insert a 32-bit object in a 64-bit Office 2010 application document.)