Quote from Scataphagos:
I've found it best to arrange my monitors to the way Windows assigns the ports rather than trying to shift the port alignments to my choice. It seems doing so puts a little "strain" on the setup... and every so often, Windows succumbs to it and resets them it ITS liking... to allleviate that strain.
My current, "stable" arrangement is 2-3-6-4-1. I'm not using "5". Prior, I tried to use 1-through-5, and that produced the unstable setup... Windows would go along with that for a while, then "rearrange things" on my next boot... it did more than just rearrange the display number... 3 monitors would go dark, portrait rotation would be lost, resolution of the primary would change, and icons would be scattered. Basically, Windows just didn't like my setup.... in spite of the fact it would tolerate if for a while.