Although gnome is probably right about many markets going 24 hours you will have noticed with the currency markets that the "openness" varies. The majority of tradable movement in a market takes place while its nationals /national institutions are active.
That effect may actually stop the total spread of 24 hourism ... are there enough customers?
So at midnight in the US look for trading in the aussie SPI, the HSI, the Nikkei etc not on the then boring SPY.