Source of the epidemic
Epidemiological studies conducted in the UK suggest that the source of BSE was cattle feed prepared from bovine tissues, such as brain and spinal cord, that was contaminated by the BSE agent.
Speculation as to the cause of the appearance of the agent causing the disease has ranged from spontaneous occurrence in cattle, the carcasses of which then entered the cattle food chain, to entry into the cattle food chain from the carcasses of sheep with a similar disease, scrapie.
Cause
BSE in the brain affects the brain and spinal cord of cattle. Lesions are characterized by sponge-like changes visible with an ordinary microscope.
The agent is highly stable, resisting freezing, drying and heating at normal cooking temperatures, even those used for pasteurization and sterilization.
The nature of the BSE agent is still a matter of debate. According to the prion theory, the agent is composed largely, if not entirely, of a self-replicating protein, referred to as a prion. Another theory argues that the agent is virus-like and possesses nucleic acids which carry genetic information. Strong evidence collected over the past decade supports the prion theory, but the ability of the BSE agent to form multiple strains is more easily explained by a virus-like agent.
Cases of BSE
Between November 1986 and November 2002, 181 376 cases of BSE were confirmed in the UK.
Since 1989, when the first BSE case was reported outside the UK, relatively small numbers of BSE cases (in total 3286) have also been reported in native cattle in Austria, Belgium, Czech Republic, Denmark, Finland, France, Germany, Greece, Ireland, Israel, Italy, Japan, Liechtenstein, Luxembourg, Netherlands, Poland, Portugal, Slovakia, Spain and Switzerland. However, all but 206 cases have been reported in six countries â France, Germany, Ireland, Portugal, Spain and Switzerland.
Since the introduction of monitoring programmes to detect BSE in dead and slaughtered cattle, 12 countries have found their first native case (Austria, Czech Republic, Finland, Germany, Greece, Israel, Italy, Japan, Poland, Slovakia, Slovenia, Spain). Small numbers of cases have also been reported in Canada, the Falkland Islands (Islas Malvinas) and Oman, but solely in animals imported from the UK. The International Office for Epizootic Diseases (OIE) reports these cases on their web site:
www.oie.int