Here is a good report on Martin's crimes. Shkreli obviously failed at trading and then turned to defrauding.
http://www.newsweek.com/martin-shkreli-drug-manipulation-daraprim-retrophin-375416
http://www.newsweek.com/martin-shkreli-drug-manipulation-daraprim-retrophin-375416
Throughout the time that the data obtained by the government suggests Shkreli was engaging in significant and undisclosed self-dealing, he was aggressively selling Retrophin stock. For example, on May 29, 2014, Shkreli posted extremely bullish messages on the Internet, which he called “non-non-non-GAAP guidance,” and proclaimed on Twitter, without explanation, “this is one of the best days of my life.” The next day, he unloaded 292,400 shares of Retrophin, earning about $4.5 million in profits. Then, the day after, Retrophin revealed the magnitude of its problem with its internal controls and accounting, a fact that, as an insider and the top executive, Shkreli would almost certainly have known when he sold his stock 24-hours before. Around that time, Retrophin terminated its accounting firm that kept delivering the bad news about the company’s controls.