dest's overwrite journal

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tsznecki said:
Yeah dozu888 I'm not sure you want to be calling others out after you screamed long all the way down in March 2020 then gave up/puked at the low and then came back 2 months later when SPX was up 20-25%.

I can dig up your posts if you'd like. Did you ever get back long again?
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I had stupid risk in AMZN which colored my outlook. I could right a check for the strip mall where his shitty little coffee shop is located.
 
destriero said:
I only do cubensis or LSD for the neuroplasticity and neurogenesis. No herb, drinking, smoking.
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If you happen to pass through southern Colorado this summer, I've got a spot for all the P. cubensis (and A. muscaria, if you like those) you could ever want. Oddly, despite being a major mycology geek/fungivore, I've never indulged in either - although I keep meaning to "one day soon".

I've seen quite a bit of the research, and there are some really impressive results with relief of anxiety and depression in terminal care - but I haven't yet seen anything reliable on neuroplasticity or neurogenesis. Shitloads of subjective info that I do trust from friends who use it to get high on, but that doesn't exactly count. :)
 
destriero said:
https://pubmed.ncbi.nlm.nih.gov/23727882/

https://observatory.synthesisretreat.com/neurogenesis-can-psilocybin-help-grow-your-brain-cells

https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30755-1
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Awesome - thanks!

P.S. Notable: "Mice injected with low doses of PSOP extinguished cued fear conditioning significantly more rapidly than high-dose PSOP [...]" This replicates the results from a lot of other research; low doses have a greater effect in a number of scenarios.

Dammit, now I'm going to have to take the time to try it out.
 
vinc said:
another perspective:

https://elifesciences.org/articles/62878

I wonder if 'placebo effect' can cause neurogenesis..not in mice probably :)
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Hard to say... we tried surveying the mouse demographic that uses psilocybins recreationally, but they couldn't be arsed to put down the plate of brownies and get off the couch. [shrug] I guess the science on this vital issue will have to remain cloudy.

(Sorry about the thread drift, dest... we're just entertaining ourselves while waiting for more good stuff. :) )
 
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