First thing I'd check is if there is any software running the cpu at a high % all the time. Does it happen as soon as you turn the computer on or after the OS starts, etc. Definitely check if there's a BIOS firmware update available.
I'd say probably the GPU fans clogged with dust, that can be loud. Check that, the PSU and the CPU fans. I opened my case while it was running and was able to tell directly where it was coming from.
If cleaning with an air compressor, I'd make sure to have a moisture trap on it. You can pick up an inline one for cheap. Also, use something to keep your fans from spinning while you dust it out if you're hitting it with high psi.