I wonder about this. The thing I don't know is the distribution of these early addresses moving coins. If it happened all throughout the other cycles, then its no big deal. But if all of a sudden, there is a larger number of these addresses cashing out, I wonder if this means anything. Perhaps they are getting tired of waiting for 6 digits, or perhaps they need the money now... hard to say. I'm also not sure if anyone back then had the foresight to picture 5 or 6 digit Bitcoin. I doubt its addresses that were locked out, and the people just found the private keys now, but this is also possible.
I guess what I'm saying is that if there is a disproportionately high number of these original addresses moving coins now, it might signal that these early players are seeing a top, or else why not hold for what will hopefully be a very healthy bull market that is just around the corner.